PolIII Cancer Research Results

PolIII, RNA Polymerase III: Click to Expand ⟱
Source:
Type:

RNA Polymerase III - DNA-Directed RNA Polymerase III

Abbreviation: RNA Pol III, Pol III, RNAPIII

Type: Nuclear DNA-dependent RNA polymerase / non-coding RNA transcription complex

Function: RNA polymerase III transcribes several abundant small non-coding RNAs required for protein synthesis and cellular growth, including transfer RNAs (tRNAs), 5S ribosomal RNA, and 7SL RNA. Pol III transcription is regulated by transcription factors including TFIIIB and TFIIIC and is closely coupled to cellular growth and nutrient signaling.

Cancer: ↑ Frequently increased or hyperactivated in transformed cells. Elevated Pol III transcription increases production of tRNAs, 5S rRNA, and other small RNAs required to sustain high rates of protein synthesis and tumor-cell proliferation. Oncogenic factors including MYC stimulate Pol III transcription, whereas tumor suppressors including TP53 and RB normally repress the pathway.
Scientific Papers found: Click to Expand⟱
Showing Research Papers: 0 to 0 of 0

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 0

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PolIII, RNA Polymerase III
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1704  State#:%  Dir#:%
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