autophagy Cancer Research Results

autophagy, autophagy: Click to Expand ⟱
Source:
Type:

Autophagy - Macroautophagy / Autophagic-Lysosomal Pathway

Abbreviation: Autophagy, Macroautophagy

Type: Cellular degradation pathway / lysosomal quality-control process

Function: Autophagy is a conserved cellular recycling pathway in which cytoplasmic proteins, damaged organelles, protein aggregates, and other cellular components are enclosed within autophagosomes and delivered to lysosomes for degradation. Major regulators include ULK1/ATG13, BECN1, VPS34, ATG5, ATG7, LC3, p62/SQSTM1, mTOR, and AMPK.

Cancer: ↕ Context-dependent. Autophagy can suppress tumor initiation by removing damaged organelles, limiting oxidative stress, and maintaining genomic stability. In established cancers, however, increased autophagy can support tumor-cell survival during hypoxia, nutrient deprivation, metabolic stress, and anticancer treatment and can contribute to treatment resistance. The biological effect therefore depends strongly on tumor type and disease stage.

Alzheimer's Disease: ↓ / impaired autophagic flux. Alzheimer's disease is characterized by dysfunction of the autophagic-lysosomal pathway, including impaired autophagosome maturation and lysosomal clearance. Defective autophagy contributes to accumulation of amyloid-β, phosphorylated tau, damaged mitochondria, and other abnormal proteins. Restoration of effective autophagic flux is generally considered neuroprotective.
Scientific Papers found: Click to Expand⟱
7837- ISQ,    Isoquercitrin Delays Denervated Soleus Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation
- in-vivo, Nor, NA
*Dose↝, *autophagy↓, *ATG7↓, *BNIP3↓, *LC3B↓, *PINK1↓, *ROS↓, *SOD1↑, *SOD2↑, *NRF2↑, *NQO1↑, *HO-1↑, *NOX2↓, *NOX4↓, *DUOX1↓, *IL1β↓, *IL6↓, *TNF-α↓, *JAK↓, *STAT3↓, *Inflam↓,
8242- LCA,    Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide/d-galactosamine-induced acute liver injury by licochalcone A
- in-vivo, LiverDam, NA
*ALAT↓, *AST↓, *Inflam↓, *ROS↓, *TLR4↓, *MAPK↓, *NF-kB↓, *TXNIP↓, *NLRP3↓, *NRF2↑, *p62↑, *hepatoP↑, *autophagy↑,
7831- PCA,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*BBB↑, *neuroP↑, *Aβ↓, *p‑tau↓, *autophagy↓, *GSK‐3β↓, *NeuroI↓, *iNOS↓, *COX2/PTGS2↓, *BDNF↑, *MEF2D↑, *cognitive↑, *memory↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

autophagy↓, 2,   autophagy↑, 1,   DUOX1↓, 1,   MEF2D↑, 1,   NeuroI↓, 1,   NOX2↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

HO-1↑, 1,   NOX4↓, 1,   NQO1↑, 1,   NRF2↑, 2,   ROS↓, 2,   SOD1↑, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PINK1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   ATG7↓, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,   MAPK↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

BNIP3↓, 1,   LC3B↓, 1,   p62↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

TXNIP↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 2,   JAK↓, 1,   NF-kB↓, 1,   TLR4↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 1,  
Total Targets: 45

Scientific Paper Hit Count for: autophagy, autophagy
1 isoquercitrin
1 Licochalcone A
1 Protocatechuic acid
1 Mung Bean Sprouts
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1709  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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