Database Query Results : , , KLF4

KLF4, Kruppel-like factor 4: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
KLF4 (Kruppel-like factor 4) is a transcription factor that plays a significant role in various biological processes, including cell differentiation, proliferation, and apoptosis.
KLF4 has a complex role in cancer, acting as both a tumor suppressor and an oncogene depending on the specific cancer type and context.

In many cancers, KLF4 acts as a tumor suppressor, where its downregulation is associated with increased tumor growth, invasion, and poor prognosis. This is often due to its role in regulating genes involved in cell cycle control, differentiation, and apoptosis.

KLF4 levels, which plays an important role in stem cell formation.
Scientific Papers found: Click to Expand⟱
2701- BBR,    Berberine Inhibits KLF4 Promoter Methylation and Ferroptosis to Ameliorate Diabetic Nephropathy in Mice
- in-vivo, Diabetic, NA
*Inflam↓, *antiOx↑, *Ferroptosis↓, *RenoP↑, *DNMT1↓, *DNMTs↓, *KLF4↑,
1435- GEN,  SFN,    The Effects of Combinatorial Genistein and Sulforaphane in Breast Tumor Inhibition: Role in Epigenetic Regulation
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7
DNMTs↓, HDAC↓, eff↑, TumCCA↑, HMTs↓, HDAC2↓, HDAC3↓, KLF4↓, hTERT/TERT↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

hTERT/TERT↓, 1,  

DNA Damage & Repair ⓘ

DNMTs↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   HMTs↓, 1,   KLF4↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Clinical Biomarkers ⓘ

hTERT/TERT↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Ferroptosis↓, 1,  

Cell Death ⓘ

Ferroptosis↓, 1,  

DNA Damage & Repair ⓘ

DNMT1↓, 1,   DNMTs↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

KLF4↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Functional Outcomes ⓘ

RenoP↑, 1,  
Total Targets: 8

Scientific Paper Hit Count for: KLF4, Kruppel-like factor 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:173  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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