Cer Cancer Research Results

Cer, ceramide: Click to Expand ⟱

Source:

Type:

Ceramide - Bioactive Sphingolipid

Type: Sphingolipid / bioactive lipid mediator / metabolic intermediate

Function: Ceramide is a central intermediate in sphingolipid metabolism and a bioactive signaling lipid generated through de novo synthesis, sphingomyelin hydrolysis, and salvage pathways. Ceramide regulates apoptosis, cell-cycle arrest, autophagy, mitophagy, necroptosis, oxidative stress, mitochondrial function, membrane organization, and inflammatory signaling. Individual ceramide species differ according to fatty-acyl chain length and can have distinct biological effects.

Cancer: ↕ Context-dependent. Ceramide accumulation frequently promotes cancer-cell death through apoptosis, mitochondrial dysfunction, mitophagy, necroptosis, and cellular stress signaling. Many cancers reduce pro-death ceramide signaling by converting ceramide into sphingosine-1-phosphate, glucosylceramide, or sphingomyelin. However, selected ceramide species can support tumor-cell survival depending on chain length, cellular compartment, and cancer type.

Alzheimer's Disease: ↑ Ceramide levels are frequently elevated in Alzheimer's disease and can increase early in disease progression. Elevated ceramide promotes amyloid-β accumulation, oxidative stress, lipid peroxidation, mitochondrial dysfunction, neuroinflammation, and neuronal apoptosis and is associated with cognitive decline and increased risk of Alzheimer's disease.

Scientific Papers found: Click to Expand⟱

8012-

itraC,

Effects and mechanism of itraconazole on prostate cancer PC-3 cell apoptosis

in-vitro,

Pca,

PC3

Apoptosis↑, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑Akt↓, mTORC1↓, i-Cer↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

i-Cer↑, 1,

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1, Apoptosis↑, 1, BAX↑, 1, Bcl-2↓, 1, cl‑Casp3↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTORC1↓, 1,
Total Targets: 7

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: Cer, ceramide

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells