GAD1/GAD67 Cancer Research Results

GAD1/GAD67, Glutamate Decarboxylase 1 / GAD67: Click to Expand ⟱
Source:
Type:

GAD1 - Glutamate Decarboxylase 1 / GAD67

Abbreviation: GAD1, GAD67

Type: Neurotransmitter-synthesis enzyme / glutamate decarboxylase

Function: GAD1 encodes the 67-kDa isoform of glutamate decarboxylase, GAD67, which converts glutamate to the inhibitory neurotransmitter GABA. GAD67 provides a major source of basal cellular GABA synthesis and is widely used as a marker of GABAergic neurons.

Cancer: ↑ Increased GAD67 expression has been reported in multiple solid cancers and can promote GABA production, metabolic reprogramming, proliferation, migration, and invasion. High GAD67 has been associated with aggressive tumor behavior and poorer clinical outcomes in several cancer types.

Alzheimer's Disease: ↓ GAD67 and other components of GABAergic neurotransmission are reduced in Alzheimer's disease brain, consistent with loss or dysfunction of inhibitory interneurons and impaired GABAergic signaling.
Scientific Papers found: Click to Expand⟱
8084- KAE,    Kaempferol treatment ameliorates memory impairments in STZ‑induced neurodegeneration by acting on reelin signaling
- in-vivo, AD, NA
*Learn↑, *memory↑, *GAD1/GAD67↑, *RELN↑, *p‑NMDAR↑, *neuroP↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

GAD1/GAD67↑, 1,   Learn↑, 1,   p‑NMDAR↑, 1,   RELN↑, 1,  

Functional Outcomes(tgid=23) ⓘ

memory↑, 1,   neuroP↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: GAD1/GAD67, Glutamate Decarboxylase 1 / GAD67
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1759  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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