Database Query Results : , , MMP1

MMP1, Matrix metalloproteinases: Click to Expand ⟱
Source:
Type:
MMP-1, or matrix metalloproteinase-1, is an enzyme that plays a significant role in the degradation of extracellular matrix components, particularly collagen. It is part of a larger family of matrix metalloproteinases (MMPs) that are involved in various physiological and pathological processes, including tissue remodeling, wound healing, and inflammation.
MMP-1 facilitates the breakdown of the extracellular matrix, which can promote tumor invasion into surrounding tissues and the spread of cancer cells to distant sites (metastasis). By degrading collagen and other matrix components, MMP-1 can help create pathways for cancer cells to migrate. Elevated levels of MMP-1 have been associated with poor prognosis in various types of cancer, including breast, lung, and colorectal cancers.
- In many cancers, high MMP-1 expression levels have been correlated with poor prognosis, indicating that it may serve as a potential biomarker for assessing tumor aggressiveness and patient outcomes.
Scientific Papers found: Click to Expand⟱
4811- ASTX,    Astaxanthin reduces MMP expressions, suppresses cancer cell migrations, and triggers apoptotic caspases of in vitro and in vivo models in melanoma
- vitro+vivo, Melanoma, A375 - vitro+vivo, Melanoma, A2058
ROS↓, MMPs↓, TumCMig↓, TumMeta↓, TumCCA↑, antiOx↑, MMP1↓, MMP2↓, MMP9↓,
1396- BBR,    Berberine induced down-regulation of matrix metalloproteinase-1, -2 and -9 in human gastric cancer cells (SNU-5) in vitro
- in-vitro, GC, SNU1041 - in-vitro, GC, SNU5
tumCV↓, ROS↑, MMP1↓, MMP2↓, MMP9↓, MMP7∅,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1↓, PGE2↓, COX2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
2775- Bos,    The journey of boswellic acids from synthesis to pharmacological activities
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
ROS↑, ER Stress↑, TumCG↓, Apoptosis↑, Inflam↓, ChemoSen↑, Casp↑, ERK↓, cl‑PARP↑, AR↓, cycD1/CCND1↓, VEGFR2↓, CXCR4↓, radioP↑, NF-kB↓, VEGF↓, P21↑, Wnt↓, β-catenin/ZEB1↓, Cyt‑c↑, MMP2↓, MMP1↓, MMP9↓, PI3K↓, MAPK↓, JNK↑, *5LO↓, *NRF2↑, *HO-1↑, *MDA↓, *SOD↑, *hepatoP↑, *ALAT↓, *AST↓, *LDH↑, *CRP↓, *COX2↓, *GSH↑, *ROS↓, *Imm↑, *Dose↝, *eff↑, *neuroP↑, *cognitive↑, *IL6↓, *TNF-α↓,
4913- DSF,    Anticancer effects of disulfiram: a systematic review of in vitro, animal, and human studies
- Review, Var, NA
Apoptosis↑, tumCV↑, eff↑, toxicity↓, antiNeop↑, ChemoSen↑, RadioS↑, OS↑, ROS↑, SOD↓, MMP1↓, eff↑, Half-Life↓,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, eff↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
2824- FIS,    Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics
- Review, Var, NA
*antiOx↑, *Inflam↓, angioG↓, BioAv↓, BioAv↑, TumCP↓, TumCI↓, TumCMig↓, *neuroP↑, EMT↓, ROS↑, selectivity↑, EGFR↓, NF-kB↓, VEGF↓, MMP9↓, MMP↓, cl‑PARP↑, Casp7↑, Casp8↑, Casp9↑, *ROS↓, uPA↓, MMP1↓, Wnt↓, Akt↓, PI3K↓, ERK↓, Half-Life↝,
2843- FIS,    Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
- Review, Var, NA
NRF2↑, Keap1↓, ChemoSen↑, BioAv↓, Cyt‑c↑, Casp3↑, Casp9↑, BAX↑, tumCV↓, Mcl-1↓, cl‑PARP↑, IGF-1↓, Akt↓, CDK6↓, TumCCA↑, P53?, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, MMP2↓, MMP9↓, MMP1↓, MMP7↓, MMP3↓, VEGF↓, PI3K↓, mTOR↓, COX2↓, Wnt↓, EGFR↓, NF-kB↓, ERK↓, ROS↑, angioG↓, TNF-α↓, PGE2↓, iNOS↓, NO↓, IL6↓, HSP70/HSPA5↝, HSP27↝,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
2911- LT,    Luteolin targets MKK4 to attenuate particulate matter-induced MMP-1 and inflammation in human keratinocytes
- in-vitro, Nor, HaCaT
*MMP1↓, *COX2↓, *IL6↓, *AP-1↓, *NF-kB↓, *ROS↓, *p‑MKK4↑, *p‑JNK↓, *p‑p38↓,
498- MF,    Stimulation of osteogenic differentiation in human osteoprogenitor cells by pulsed electromagnetic fields: an in vitro study
- in-vitro, NA, NA
Calcium↑, MMP1↑, MMP3↑, BMPs↑,
3745- MFrot,  MF,    The neurobiological foundation of effective repetitive transcranial magnetic brain stimulation in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *ROS↓, *Inflam↓, *5HT↑, *cFos↑, *Aβ↓, *memory↑, *BDNF↑, *Ach↑, *AChE↓, *cognitive↑, *BDNF↑, *NGF↑, *β-catenin/ZEB1↑, *p‑Akt↓, *mTOR↓, *MMP1↓, *MMP9↓, *MMP-10↓, *TIMP1↑, *TIMP2↑,
1239- PACs,    Cranberry proanthocyanidins inhibit MMP production and activity
- in-vitro, Nor, NA
*MMPs↓, *MMP1↓, *MMP9↓, *NF-kB↓,
1680- PBG,    Protection against Ultraviolet A-Induced Skin Apoptosis and Carcinogenesis through the Oxidative Stress Reduction Effects of N-(4-bromophenethyl) Caffeamide, a Propolis Derivative
- in-vitro, Nor, HS68
*ROS↓, *NRF2↑, *HO-1↑, *cJun↓, *MMP1↓, *MMP2↓, *p‑cJun↓, *cFos↓, *BAX↓, *Casp3↓, *DNAdam↓, *iNOS↓, *COX2↓, *IL6↓, *PGE2↓, *NO↓,
1508- SFN,    Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment
- Review, Var, NA
*BioAv↑, HDAC↓, TumCCA↓, eff↓, Wnt↓, β-catenin/ZEB1↓, Casp12?, Bcl-2↓, cl‑PARP↑, Bax:Bcl2↑, IAP1↓, Casp3↑, Casp9↑, Telomerase↓, hTERT/TERT↓, ROS?, DNMTs↓, angioG↓, VEGF↓, Hif1a↓, cMYB↓, MMP1↓, MMP2↓, MMP9↓, ERK↑, E-cadherin↑, CD44↓, MMP2↓, eff↑, IL2↑, IFN-γ↑, IL1β↓, IL6↓, TNF-α↓, NF-kB↓, ERK↓, NRF2↑, RadioS↑, ChemoSideEff↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 16

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

chemoPv↑, 1,  

Redox & Oxidative Stress ⓘ

antiOx↑, 1,   antiOx⇅, 1,   CYP1A1↓, 1,   GSTs↓, 1,   HO-1↑, 1,   Keap1↓, 1,   lipid-P?, 1,   NRF2↓, 1,   NRF2↑, 2,   ROS?, 1,   ROS↓, 1,   ROS↑, 8,   SOD↓, 1,  

Metal & Cofactor Biology ⓘ

Tf↓, 1,  

Mitochondria & Bioenergetics ⓘ

CDC25↓, 2,   EGF↓, 1,   MMP↓, 3,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

ACC↑, 1,   AMPK↑, 2,   FASN↓, 1,   PPARα↓, 1,  

Cell Death ⓘ

Akt↓, 4,   Apoptosis↑, 4,   BAD↑, 1,   BAX↑, 4,   Bax:Bcl2↑, 1,   Bcl-2↓, 3,   Bcl-xL↓, 2,   BIM↑, 1,   Casp↑, 2,   Casp12?, 1,   Casp3↓, 1,   Casp3↑, 4,   Casp7↑, 1,   Casp8↑, 3,   Casp9↑, 4,   Cyt‑c↑, 4,   Diablo↑, 1,   DR4↑, 1,   DR5↑, 2,   Fas↑, 2,   FasL↑, 1,   hTERT/TERT↓, 1,   IAP1↓, 2,   iNOS↓, 1,   JNK↑, 2,   MAPK↓, 3,   Mcl-1↓, 2,   MDM2↓, 1,   Myc↓, 1,   p27↑, 1,   p38↓, 1,   survivin↓, 1,   Telomerase↓, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   other↓, 1,   tumCV↓, 2,   tumCV↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,   HSP27↓, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↝, 1,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

ATM↑, 1,   DNAdam↑, 1,   DNMTs↓, 1,   P53?, 1,   P53↑, 3,   cl‑PARP↑, 6,  

Cell Cycle & Senescence ⓘ

CDK2↓, 4,   CDK4↓, 3,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 2,   P21↑, 3,   RB1↑, 1,   p‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 1,   cFos↓, 1,   cMYB↓, 1,   EMT↓, 2,   EMT↑, 1,   ERK↓, 6,   ERK↑, 1,   p‑ERK↓, 1,   HDAC↓, 1,   IGF-1↓, 2,   Let-7↑, 1,   mTOR↓, 3,   PI3K↓, 5,   RAS↓, 1,   STAT3↓, 1,   TOP1↓, 2,   TOP2↓, 1,   TOP2↑, 1,   TumCG↓, 1,   Wnt↓, 6,  

Migration ⓘ

E-cadherin↑, 2,   FAK↓, 2,   Fibronectin↓, 1,   MET↓, 1,   miR-200b↑, 1,   MMP1↓, 11,   MMP1↑, 1,   MMP13↓, 1,   MMP2↓, 9,   MMP3↓, 3,   MMP3↑, 1,   MMP7↓, 2,   MMP7∅, 1,   MMP9↓, 10,   MMPs↓, 1,   N-cadherin↓, 1,   PDGF↓, 2,   PKCδ↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TumCI↓, 3,   TumCMig↓, 2,   TumCP↓, 3,   TumMeta↓, 4,   Twist↓, 2,   uPA↓, 3,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 7,   ATF4↓, 1,   EGFR↓, 4,   eNOS↓, 1,   Hif1a↓, 2,   NO↓, 1,   p‑PDGFR-BB↓, 1,   VEGF↓, 8,   VEGFR2↓, 2,  

Immune & Inflammatory Signaling ⓘ

CD4+↓, 1,   COX2↓, 5,   CXCR4↓, 2,   IFN-γ↑, 1,   IKKα↓, 1,   IL1↓, 1,   IL1α↓, 1,   IL1β↓, 1,   IL2↑, 1,   IL6↓, 3,   Inflam↓, 2,   MCP1↓, 2,   MIP2↓, 1,   NF-kB↓, 10,   p65↓, 1,   PGE2↓, 2,   TNF-α↓, 3,  

Synaptic & Neurotransmission ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,   CDK6↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 5,   BioAv↑, 3,   ChemoSen↑, 6,   CYP1A2↓, 1,   Dose↑, 1,   Dose↝, 1,   eff↓, 1,   eff↑, 10,   Half-Life↓, 2,   Half-Life↝, 1,   P450↓, 1,   RadioS↑, 2,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

AR↓, 2,   ascitic↓, 1,   BMPs↑, 1,   Calcium↑, 1,   EGFR↓, 4,   hTERT/TERT↓, 1,   IL6↓, 3,   Myc↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   antiNeop↑, 1,   AntiTum↑, 1,   chemoP↑, 1,   ChemoSideEff↓, 1,   OS↑, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 2,  
Total Targets: 194

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   Catalase↑, 2,   GPx↑, 1,   GSH↑, 1,   GSR↑, 1,   GSTA1↑, 1,   HO-1↑, 2,   MDA↓, 1,   NRF2↑, 3,   ROS↓, 7,   SOD↑, 2,  

Mitochondria & Bioenergetics ⓘ

p‑MKK4↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   LDH↑, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   BAX↓, 1,   Casp3↓, 1,   iNOS↓, 1,   p‑JNK↓, 1,   MAPK↑, 1,   p‑p38↓, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   cJun↓, 1,   p‑cJun↓, 1,   other↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

cFos↓, 1,   cFos↑, 1,   mTOR↓, 1,  

Migration ⓘ

5LO↓, 1,   AP-1↓, 1,   Ca+2↝, 1,   MMP-10↓, 1,   MMP1↓, 4,   MMP2↓, 1,   MMP9↓, 2,   MMPs↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   CRP↓, 1,   IL6↓, 3,   Imm↑, 1,   Inflam↓, 4,   NF-kB↓, 3,   PGE2↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   AChE↓, 1,   BDNF↑, 2,   NGF↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   Dose↝, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,   CRP↓, 1,   IL6↓, 3,   LDH↑, 1,  

Functional Outcomes ⓘ

cognitive↑, 2,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 4,  
Total Targets: 66

Scientific Paper Hit Count for: MMP1, Matrix metalloproteinases
3 Fisetin
2 Berberine
2 Boswellia (frankincense)
2 Luteolin
2 Magnetic Fields
1 Astaxanthin
1 Disulfiram
1 Magnetic Field Rotating
1 Proanthocyanidins
1 Propolis -bee glue
1 Sulforaphane (mainly Broccoli)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:198  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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