Database Query Results : , , MUC1

MUC1, Mucin 1: Click to Expand ⟱
Source:
Type: oncoprotein
The mucin 1 (MUC1) heterodimeric oncoprotein is overexpressed in human prostate cancers with aggressive pathologic and clinical features, resulting in a poor MUC1 (Mucin 1) is a glycoprotein that is expressed on the surface of epithelial cells and plays a role in cell signaling, protection, and lubrication. It is also involved in various biological processes, including cell adhesion and immune response outcome.
MUC1 is often overexpressed in various types of cancers, including breast, ovarian, pancreatic, and colorectal cancers.
Scientific Papers found: Click to Expand⟱
144- CUR,  Bical,    Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-κB/p65 and MUC1-C
- in-vitro, Pca, PC3 - in-vitro, NA, DU145 - in-vitro, NA, LNCaP
p‑ERK↑, p‑JNK↓, MUC1↓, p65↓,
59- QC,    Quercetin Inhibits Breast Cancer Stem Cells via Downregulation of Aldehyde Dehydrogenase 1A1 (ALDH1A1), Chemokine Receptor Type 4 (CXCR4), Mucin 1 (MUC1), and Epithelial Cell Adhesion Molecule (EpCAM)
- in-vitro, BC, MDA-MB-231
ALDH1A1↓, CXCR4↓, MUC1↓, EpCAM↓,
1575- statins,  Citrate,    Inhibition of Lung Cancer Growth: ATP Citrate Lyase Knockdown and Statin Treatment Leads to Dual Blockade of Mitogen-Activated Protein Kinase (MAPK) and Phosphatidylinositol-3-Kinase (PI3K)/AKT Pathways
- in-vitro, NSCLC, A549
eff↑, HMG-CoA↓, eff↑, AntiTum↑, EGFR↓, eff↑, ROS↑, EMT↓, E-cadherin↑, MUC1↑, p‑ACLY↓, p‑Akt↓, eff↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

p‑ACLY↓, 1,   HMG-CoA↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   p‑JNK↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ALDH1A1↓, 1,   EMT↓, 1,   EpCAM↓, 1,   p‑ERK↑, 1,  

Migration ⓘ

E-cadherin↑, 1,   MUC1↓, 2,   MUC1↑, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,  

Immune & Inflammatory Signaling ⓘ

CXCR4↓, 1,   p65↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 4,  

Clinical Biomarkers ⓘ

EGFR↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,  
Total Targets: 18

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MUC1, Mucin 1
1 Curcumin
1 Bicalutamide
1 Quercetin
1 statins
1 Citric Acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:206  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page