Database Query Results : , , CTGF

CTGF, Connective Tissue Growth Factor: Click to Expand ⟱
Source:
Type: prognostic biomarker
CTGF is a matricellular protein that belongs to the CCN (Cyr61/CTGF/Nov) family. It plays a pivotal role in diverse biological processes, including cell adhesion, migration, proliferation, and differentiation. CTGF is also involved in wound healing and fibrosis. In cancer, CTGF’s function is multifaceted, affecting tumor growth, angiogenesis, and the remodeling of the tumor microenvironment.

CTGF is overexpressed in several cancer types, such as pancreatic, breast, and prostate cancers. In these contexts, higher levels of CTGF have been associated with enhanced tumor growth, angiogenesis, and metastasis.

Elevated CTGF expression often correlates with adverse clinical features.
Scientific Papers found: Click to Expand⟱
1117- Gb,    Ginkgobiloba leaf extract mitigates cisplatin-induced chronic renal interstitial fibrosis by inhibiting the epithelial-mesenchymal transition of renal tubular epithelial cells mediated by the Smad3/TGF-β1 and Smad3/p38 MAPK pathways
- vitro+vivo, Kidney, HK-2
α-SMA↓, COL1↓, TGF-β↓, SMAD2↓, SMAD3↓, p‑SMAD2↓, p‑SMAD3↓, p38↓, p‑p38↓, Vim↓, TIMP1↓, CTGF↓, E-cadherin↑, MMP1:TIMP1↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

p38↓, 1,   p‑p38↓, 1,  

Migration ⓘ

COL1↓, 1,   CTGF↓, 1,   E-cadherin↑, 1,   MMP1:TIMP1↑, 1,   SMAD2↓, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↓, 1,   TGF-β↓, 1,   TIMP1↓, 1,   Vim↓, 1,   α-SMA↓, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CTGF, Connective Tissue Growth Factor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:211  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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