Database Query Results : , , nucleolin

nucleolin, nucleolin: Click to Expand ⟱
Source:
Type:
In addition, nucleolin expressed at the cell surface binds a variety of ligands that have been implicated in tumorigenesis and angiogenesis.
expression and localization of nucleolin is often abnormal in cancers.
Meng et al6 indicated that a decrease of cell-surface nucleolin expression, or activity would inhibit the growth of cancer cells and trigger the apoptosis in endothelial cells.
Dysregulated accumulation of nucleolin mRNA and protein is found in a diverse range of cancers, and the level of surface nucleolin in cancers is much higher than in normal cells.7 The elevated expression of nucleolin is associated with a worse prognosis of cancer patients, and the presence of nucleolin on the cell surface increases the malignancy of cancer and modulates the metastasis.
Scientific Papers found: Click to Expand⟱
219- MFrot,  MF,    The expression and intranuclear distribution of nucleolin in HL-60 and K-562 cells after repeated, short-term exposition to rotating magnetic fields
- in-vitro, AML, HL-60 - in-vitro, AML, K562
nucleolin↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Angiogenesis & Vasculature ⓘ

nucleolin↑, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: nucleolin, nucleolin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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