Database Query Results : , , AXIN1

AXIN1, Axis inhibition protein 1: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
AXIN1 is a tumor suppressor and a crucial negative regulator of the Wnt/β-catenin signaling pathway. Abnormal expression of AXIN1 protein has been shown to be associated with various tumors, including CRC.
Axin1 Protein expression was decreased remarkably in tumor specimens when compared to normal tissues. Alterations of Axin1 including AXIN1 gene mutations and decreased Axin1 expression have been reported in several types of solid tumors.
Scientific Papers found: Click to Expand⟱
1103- CBD,    Cannabidiol inhibits invasion and metastasis in colorectal cancer cells by reversing epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway
- vitro+vivo, NA, NA
Apoptosis↑, TumCP↓, TumCMig↓, TumMeta↓, EMT↓, E-cadherin↑, N-cadherin↓, Snail↓, Vim↓, Hif1a↓, Wnt/(β-catenin)↓, AXIN1↑, TumVol↓, TumW↓,
442- CUR,  5-FU,    Curcumin may reverse 5-fluorouracil resistance on colonic cancer cells by regulating TET1-NKD-Wnt signal pathway to inhibit the EMT progress
- in-vitro, CRC, HCT116
Apoptosis↑, TumCP↓, TumCCA↑, TET1↑, NKD2↑, Wnt↓, EMT↓, Vim↑, E-cadherin↓, β-catenin/ZEB1↓, TCF↓, AXIN1↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 2,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

AXIN1↓, 1,   AXIN1↑, 1,   EMT↓, 2,   NKD2↑, 1,   TCF↓, 1,   Wnt↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

E-cadherin↓, 1,   E-cadherin↑, 1,   N-cadherin↓, 1,   Snail↓, 1,   TET1↑, 1,   TumCMig↓, 1,   TumCP↓, 2,   TumMeta↓, 1,   Vim↓, 1,   Vim↑, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Functional Outcomes ⓘ

TumVol↓, 1,   TumW↓, 1,  
Total Targets: 23

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: AXIN1, Axis inhibition protein 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:23  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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