Database Query Results : , , PDGFRA

PDGFRA, platelet-derived growth factor receptor, alpha polypeptide: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
PDGFRA (Platelet-Derived Growth Factor Receptor Alpha) is a receptor tyrosine kinase that plays a significant role in cell growth, survival, and differentiation. It is part of the PDGF family, which includes various growth factors that bind to PDGF receptors to regulate cellular functions.
Cancers, such as gastrointestinal stromal tumors (GISTs), are often associated with mutations in the PDGFRA gene.
Imatinib (Gleevec) is a tyrosine kinase inhibitor that is effective in treating GISTs with PDGFRA mutations.

PDGFRA overexpression is reported in several tumors. However, more notably, mutations (often gain-of-function) or gene amplifications in PDGFRA are key oncogenic events in certain cancer types.
Scientific Papers found: Click to Expand⟱
110- SFN,    Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway
- in-vivo, PC, NA
HH↓, Smo↓, Gli1↓, GLI2↓, Shh↓, VEGF↓, PDGFRA↓, EMT↓, Zeb1↓, Bcl-2↓, XIAP↓, E-cadherin↑, OCT4↓,
1733- SFN,    Sonic Hedgehog Signaling Inhibition Provides Opportunities for Targeted Therapy by Sulforaphane in Regulating Pancreatic Cancer Stem Cell Self-Renewal
- in-vitro, PC, PanCSC - in-vitro, Nor, HPNE - in-vitro, Nor, HNPSC
CSCs↓, Shh↓, Gli↓, Nanog↓, OCT4↓, PDGFRA↓, cycD1/CCND1↑, Apoptosis↑, Casp↑, Smo↓, Gli1↓, GLI2↓, Bcl-2↓, Casp3↑, Casp7↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

XIAP↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Bcl-2↓, 2,   Casp↑, 1,   Casp3↑, 1,   Casp7↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   EMT↓, 1,   Gli↓, 1,   Gli1↓, 2,   HH↓, 1,   Nanog↓, 1,   OCT4↓, 2,   PDGFRA↓, 2,   Shh↓, 2,   Smo↓, 2,  

Migration ⓘ

E-cadherin↑, 1,   GLI2↓, 2,   Zeb1↓, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↓, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PDGFRA, platelet-derived growth factor receptor, alpha polypeptide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:244  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page