Database Query Results : , , PIK3CA

PIK3CA, phosphoinositide-3-kinase, catalytic, alpha polypeptide: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
Class III PtdIns3K (PIK3C3/Vps34)
Class I phosphoinositide 3-kinase (PI3K)
In contrast to the class III PtdIns3K as a positive regulator of autophagy, class I PI3K-AKT signaling has an opposing effect on the initiation of autophagy.

PIK3CA is a gene that encodes the p110α catalytic subunit of phosphoinositide 3-kinase (PI3K), which is a key player in the PI3K/AKT signaling pathway. This pathway is crucial for various cellular processes, including growth, proliferation, survival, and metabolism.
PIK3CA is often overexpressed, which can lead to increased activity of the PI3K/AKT signaling pathway. This overexpression can contribute to tumor growth, survival, and metastasis.

Class III PtdIns3K (PIK3C3/Vps34) is central to autophagy regulation. In many tumor types, higher expression is thought to promote autophagy, which can help cancer cells survive under metabolic and therapeutic stress. This survival advantage is one reason why high PIK3C3 expression sometimes correlates with a more aggressive phenotype and poorer overall prognosis.
Scientific Papers found: Click to Expand⟱
1338- AS,    The Modulatory Properties of Astragalus membranaceus Treatment on Triple-Negative Breast Cancer: An Integrated Pharmacological Method
- in-vitro, BC, NA
TumCI↓, Apoptosis↑, Symptoms↓, PIK3CA↓, Akt↓, Bcl-2↓,
312- SNP,  wortm,    Inhibition of autophagy enhances the anticancer activity of silver nanoparticles
- vitro+vivo, NA, HeLa
APA↑, p62↓, PIK3CA↑, TumVol↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

PIK3CA↓, 1,   PIK3CA↑, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   Bcl-2↓, 1,  

Autophagy & Lysosomes ⓘ

APA↑, 1,   p62↓, 1,  

Migration ⓘ

TumCI↓, 1,  

Functional Outcomes ⓘ

Symptoms↓, 1,   TumVol↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PIK3CA, phosphoinositide-3-kinase, catalytic, alpha polypeptide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:256  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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