Database Query Results : , , PPP2R1A

PPP2R1A, protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
PPP2R1A (Protein Phosphatase 2 Regulatory Subunit A) is a gene that encodes a regulatory subunit of protein phosphatase 2A (PP2A), which is a critical enzyme involved in various cellular processes, including cell growth, division, and apoptosis.
PP2A is considered a tumor suppressor, and its activity is often reduced in cancer cells.
PP2A and PPP2R1A are often used interchangeably in the literature, but technically, PP2A refers to the enzyme itself, while PPP2R1A refers to the gene that encodes one of the subunits of the enzyme.
Scientific Papers found: Click to Expand⟱
601- HTyr,    Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells
- in-vivo, NA, HT-29
TumCG↓, Apoptosis↑, ER Stress↑, UPR↑, CHOP↑, JNK↑, TNF-α↓, PPP2R1A↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,   JNK↑, 1,   PPP2R1A↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 1,   UPR↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Immune & Inflammatory Signaling ⓘ

TNF-α↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PPP2R1A, protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:260  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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