Database Query Results : , , BRAF

BRAF, v-raf murine sarcoma viral oncogene homolog B1: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
BRAF is a gene involved in controlling cell growth.
BRAF mutations are present in approximately 10%-15% of colorectal cancers, 35% of melanomas, and more than 50% of thyroid papillary carcinomas. The majority of BRAF mutations are V600E mutations. the v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) gene mutation has been observed in esophageal cancer and is associated with poor prognosis.
It encodes a protein that is part of the RAS-RAF-MEK-ERK signaling pathway, which is involved in regulating cell division, differentiation, and survival. When BRAF is mutated, particularly in the form of the BRAF V600E mutation, it can lead to constitutive activation of the signaling pathway, promoting uncontrolled cell growth and contributing to the development of various cancers, most notably melanoma.

BRAF is used as a clinical biomarker for targeted therapy
Scientific Papers found: Click to Expand⟱
726- Bor,    Redox Mechanisms Underlying the Cytostatic Effects of Boric Acid on Cancer Cells—An Issue Still Open
- Review, NA, NA
NAD↝, SAM-e↝, PSA↓, IGF-1↓, Cyc↓, P21↓, p‑MEK↓, p‑ERK↓, ROS↑, SOD↓, Catalase↓, MDA↑, GSH↓, IL1↓, IL6↓, TNF-α↓, BRAF↝, MAPK↝, PTEN↝, PI3K/Akt↝, eIF2α↑, ATF4↑, ATF6↑, NRF2↑, BAX↑, BID↑, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓,
729- Bor,    Promising potential of boron compounds against Glioblastoma: In Vitro antioxidant, anti-inflammatory and anticancer studies
- in-vitro, GBM, U87MG - in-vivo, Nor, HaCaT
TOS↑, TumCG↓, MDA↑, SOD↑, Catalase↑, TAC↓, GSH↓, BRAF↑, MAPK↓, PTEN↓, Raf↓, *toxicity↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   Catalase↑, 1,   GSH↓, 2,   MDA↑, 2,   NRF2↑, 1,   ROS↑, 1,   SAM-e↝, 1,   SOD↓, 1,   SOD↑, 1,   TAC↓, 1,   TOS↑, 1,  

Mitochondria & Bioenergetics ⓘ

p‑MEK↓, 1,   Raf↓, 1,  

Core Metabolism/Glycolysis ⓘ

NAD↝, 1,   PI3K/Akt↝, 1,  

Cell Death ⓘ

BAX↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   BID↑, 1,   Casp3↑, 1,   Casp9↑, 1,   MAPK↓, 1,   MAPK↝, 1,  

Protein Folding & ER Stress ⓘ

ATF6↑, 1,   eIF2α↑, 1,  

Cell Cycle & Senescence ⓘ

Cyc↓, 1,   P21↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

BRAF↑, 1,   BRAF↝, 1,   p‑ERK↓, 1,   IGF-1↓, 1,   PTEN↓, 1,   PTEN↝, 1,   TumCG↓, 1,  

Angiogenesis & Vasculature ⓘ

ATF4↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL1↓, 1,   IL6↓, 1,   PSA↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

BRAF↑, 1,   BRAF↝, 1,   IL6↓, 1,   PSA↓, 1,  
Total Targets: 43

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: BRAF, v-raf murine sarcoma viral oncogene homolog B1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:31  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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