BRCA1 Cancer Research Results

BRCA1, BReast CAncer gene 1: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
BRCA1 and BRCA2 are tumor suppressor genes, which, when they function normally, keep tumors from forming.
BRCA1 mutations are associated with an increased risk for:
Breast cancer, including an aggressive form called Triple Negative Breast Cancer
Ovarian cancer
Pancreatic cancer
Prostate cancer
BRCA1/BRCA2 are used as clinical biomarker for PARP inhibitor use.
Scientific Papers found: Click to Expand⟱
735- Bor,    Boric Acid Alters the Expression of DNA Double Break Repair Genes in MCF-7-Derived Breast Cancer Stem Cells
- in-vitro, BC, NA
BRCA1↑, BRCA2↑, ATM↓,
6140- Cin,  HCAs,    Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review)
- Review, Var, NA
Dose↝, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, angioG↓, *Inflam↓, *antiOx↑, *Bacteria↓, *AntiThr↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, ChemoSen↑, *BioAv↝, *BioAv↑, eff↑, CDK1↓, CDK2↓, CDK4↓, cJun↓, cFos↓, Apoptosis↑, PI3K↓, Akt↓, E-cadherin↑, MMP2↓, MMP9↓, TOP1↓, BRCA1↓, ROS↑, BAX↑, Bcl-2↓, XIAP↓, MMP↓, STAT3↓, mTOR↓, NF-kB↓, eff↑, toxicity↓, cardioP↑,
422- CUR,    Curcumin induces re-expression of BRCA1 and suppression of γ synuclein by modulating DNA promoter methylation in breast cancer cell lines
- in-vitro, BC, HCC-38 - in-vitro, BC, T47D
BRCA1↑, TET1↑, DNMT3A↑, DNMT1↓, SNCG↓, miR-29b↓, miR-29b↑,
5055- Ex,    Why exercise has a crucial role in cancer prevention, risk reduction and improved outcomes
- Review, Var, NA
OS↑, IGF-1↓, IGFBP3↑, BRCA1↑, BRCA2↑, RAS↓, P53↑, HSPs↑, Leptin↓, Irisin↓, Resistin↓, NK cell↑, CRP↓, IL6↓, TNF-α↓, PGE1↓, COX2/PTGS2↓, *GSH↑, *Catalase↑, *SOD↑, *monoA↑, *EndoR↑, *testos↑, ROS↑, QoL↑, BMD↑, BowelM↑,
7048- GA,    Natural bioactive gallic acid shows potential anticancer effects by inhibiting the proliferation and invasiveness behavior in human embryonic carcinoma cells
- in-vitro, Var, NA
AntiCan↑, TumCCA↑, angioG↓, TumCMig↓, TumMeta↓, CSCs↓, Apoptosis↑, P21↑, P53↑, p27/CDKN1B↑, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, SOX2↓, Nanog↓, OCT4↓, ROS↑, DNAdam↑, BRCA1↑, ATM↑, CHK1↑, Chk2↑, Histones↑, TumCI↓, MMPs↓, EGFR↓, JAK2↓, STAT5↓,
7355- HibSad,    Evaluation of antitumoral effect of Hibiscus sabdariffa extract on human breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
tumCV↓, ER-α36↓, BRCA1↓, Cav1↓, Proteasome↓, TumAuto↑, TumCMig↓, TumCI↓,
7592- I3C,    Indole-3-carbinol as a chemopreventive and anti-cancer agent
- Review, Var, NA
JNK↑, STAT3↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, AhR↑, ER-α36↓, ChemoSen↑, ER Stress↑, UPR↑, BRCA1↑, BRCA2↑, TumCMig↓, TumCI↓, VEGF↓, IL8↓, MMP2↓, MMP9↓, RadioS↑, Akt↓, NF-kB↓, DR4↑, DR5↑,
7750- ISL,    Isoliquiritigenin in Breast Cancer: A Systematic Review of Its Preventive and Anti-metastatic Mechanisms
- Review, BC, NA
AntiCan↑, Apoptosis↑, TumAuto↑, mTOR↓, AApath↓, EMT↓, BRCA1↝, PI3K↓, Akt↓, angioG↓, VEGF↓, Hif1a↓, COX2/PTGS2↓, NF-kB↓,
8090- KAE,    A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
- Review, Nor, NA
*cardioP↑, *AntiCan↑, *Inflam↓, *neuroP↑, *BioAv↓, selectivity?, p‑Akt↓, p‑cycD1/CCND1↓, p‑CDK4↓, p‑BID↓, p‑Mcl-1↓, p‑BRCA1↑, ATM↑, P53↑, P21↑, p38↑, BAX↑, BID↑, MMP↓, Casp3↑, Casp7↑, Casp9↑, AIF↑, ER Stress↑, TumMeta↓, ERK↓, AP-1↓, JNK↓, p38↓, GLUT1↓, GlucoseCon↓, MMP9↓, CYP1A1↓, ChemoSen↑, OCT4↓, Nanog↓, P-gp/ABCB1↓, ALDH1A1↓, TumCCA↑, DNAdam↑, γH2AX↑, COX2/PTGS2↓, i-ROS↓, Ca+2↓, eff↑, DR5↑, ChemoSen↑, Akt↓, PI3K↓, ROS↑, EMT↓, survivin↓,
2043- PB,  Cisplatin,    Phenylbutyrate interferes with the Fanconi anemia and BRCA pathway and sensitizes head and neck cancer cells to cisplatin
- in-vitro, HNSCC, UM-SCC-1
ChemoSen↑, eff↑, HDAC↓, BRCA1↓, RadioS↑,
100- QC,    Inhibition of Prostate Cancer Cell Colony Formation by the Flavonoid Quercetin Correlates with Modulation of Specific Regulatory Genes
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4/6↓, E2Fs↓, PCNA↓, cDC2↓, PTEN↑, MSH2↑, P21↑, EP300↑, BRCA1↑, NF2↑, TSC1↑, TGFβR1↑, P53↑, RB1↑, AKT1↓, cMyc↓, CDC7↓, cycF↓, CDC16↓, CUL4B↑, CBP↑, TSC2↑, HER2/EBBR2↓, BCR↓, TumCCA↑, chemoPv↑,
1506- RES,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, NA, NA
DNMTs↓, BRCA1↑, HDAC↓, SIRT1↑, p300↓, survivin↓, HDAC1↓, HDAC3↓, HDAC8↓,
3423- TQ,    Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics
- Review, Var, NA
AntiCan↑, Inflam↓, hepatoP↑, RenoP↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, ROS↑, P53↑, PTEN↑, P21↑, p27/CDKN1B↑, BRCA1↑, PI3K↓, Akt↓, MAPK↓, ERK↓, p‑ERK↓, MMPs↓, FAK↓, Twist↓, Zeb1↓, EMT↓, TumMeta↓, angioG↓, VEGF↓, HDAC↓, Maspin↑, SIRT1↑, DNMT1↓, DNMT3A↓, HDAC1↓, HDAC4↓,
5022- UA,    Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↑, TumMeta↓, BioAv↓, Hif1a↓, Glycolysis↓, mitResp↓, Akt↓, MAPK↓, ERK↓, mTOR↓, P53↑, P21↑, E2Fs↑, STAT3↓, MMP↓, NLRP3↓, iNOS↓, CHK1↓, Chk2↓, BRCA1↓, E-cadherin↑, N-cadherin↓, Casp↑, p62↓, LC3II↑, Vim↓, ROS↑, CSCs↓, DNAdam↑, GutMicro↑, VEGF↓,

Showing Research Papers: 1 to 14 of 14

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 14

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AApath↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

CYP1A1↓, 1,   ROS↑, 6,   i-ROS↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   BCR↓, 1,   CDC16↓, 1,   mitResp↓, 1,   MMP↓, 3,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   Cav1↓, 1,   cMyc↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   Histones↑, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

AhR↑, 1,   Akt↓, 6,   p‑Akt↓, 1,   Apoptosis↑, 5,   Bak↑, 1,   BAX↑, 3,   Bcl-2↓, 2,   Bcl-xL↓, 1,   BID↑, 1,   p‑BID↓, 1,   Casp↑, 1,   Casp3↑, 1,   Casp7↑, 1,   Casp9↑, 1,   CBP↑, 1,   Chk2↓, 1,   Chk2↑, 1,   DR4↑, 1,   DR5↑, 2,   iNOS↓, 1,   JNK↓, 1,   JNK↑, 1,   MAPK↓, 2,   p‑Mcl-1↓, 1,   p27/CDKN1B↑, 3,   p38↓, 1,   p38↑, 1,   Proteasome↓, 1,   survivin↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

CDC7↓, 1,   HER2/EBBR2↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

BowelM↑, 1,   cJun↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 2,   HSPs↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3II↑, 1,   p62↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   ATM↑, 2,   BRCA1↓, 4,   BRCA1↑, 8,   BRCA1↝, 1,   p‑BRCA1↑, 1,   BRCA2↑, 3,   CHK1↓, 1,   CHK1↑, 1,   CUL4B↑, 1,   DNAdam↑, 3,   DNMT1↓, 2,   DNMT3A↓, 1,   DNMT3A↑, 1,   DNMTs↓, 1,   P53↑, 6,   PCNA↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 3,   CDK4↓, 3,   p‑CDK4↓, 1,   cycD1/CCND1↓, 3,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 3,   cycF↓, 1,   E2Fs↓, 1,   E2Fs↑, 1,   P21↑, 6,   RB1↑, 1,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   cDC2↓, 1,   cFos↓, 1,   CSCs↓, 2,   EMT↓, 3,   EP300↑, 1,   ERK↓, 3,   p‑ERK↓, 1,   HDAC↓, 3,   HDAC1↓, 2,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC8↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   mTOR↓, 3,   Nanog↓, 2,   NF2↑, 1,   OCT4↓, 2,   p300↓, 1,   PI3K↓, 4,   PTEN↑, 2,   RAS↓, 1,   SOX2↓, 1,   STAT3↓, 3,   STAT5↓, 1,   TOP1↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↓, 1,   CDK4/6↓, 1,   E-cadherin↑, 2,   ER-α36↓, 2,   FAK↓, 1,   miR-29b↓, 1,   miR-29b↑, 1,   MMP2↓, 2,   MMP9↓, 3,   MMPs↓, 2,   MSH2↑, 1,   N-cadherin↓, 1,   TET1↑, 1,   TSC1↑, 1,   TumCI↓, 4,   TumCMig↓, 4,   TumCP↓, 2,   TumMeta↓, 4,   Twist↓, 1,   Vim↓, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   angioG↑, 1,   EGFR↓, 1,   Hif1a↓, 2,   VEGF↓, 4,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   CRP↓, 1,   IL6↓, 1,   IL8↓, 1,   Inflam↓, 1,   JAK2↓, 1,   NF-kB↓, 3,   NK cell↑, 1,   PGE1↓, 1,   Resistin↓, 1,   TNF-α↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,   SNCG↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,   Irisin↓, 1,   Leptin↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   ChemoSen↑, 5,   Dose↝, 1,   eff↑, 4,   RadioS↑, 2,   selectivity?, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,   BRCA1↓, 4,   BRCA1↑, 8,   BRCA1↝, 1,   p‑BRCA1↑, 1,   CRP↓, 1,   EGFR↓, 1,   GutMicro↑, 1,   HER2/EBBR2↓, 1,   IL6↓, 1,   Maspin↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   cardioP↑, 1,   chemoPv↑, 1,   hepatoP↑, 1,   OS↑, 1,   QoL↑, 1,   RenoP↑, 1,   TGFβR1↑, 1,   toxicity↓, 1,  
Total Targets: 187

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GSH↑, 1,   SOD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

EndoR↑, 1,   monoA↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 1,   hepatoP↑, 1,   neuroP↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 18

Scientific Paper Hit Count for: BRCA1, BReast CAncer gene 1
1 Boron
1 Cinnamon
1 Hydroxycinnamic-acid
1 Curcumin
1 Exercise
1 Gallic acid
1 Hibiscus sabdariffa
1 Indole-3-carbinol
1 Isoliquiritigenin
1 Kaempferol
1 Phenylbutyrate
1 Cisplatin
1 Quercetin
1 Resveratrol
1 Thymoquinone
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:32  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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