BRCA2 Cancer Research Results

BRCA2, BReast CAncer gene 2: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
BRCA1 and BRCA2 are tumor suppressor genes, which, when they function normally, keep tumors from forming.
BRCA2 mutations are associated with an increased risk for:
Breast cancer
Ovarian cancer
Melanoma
Pancreatic cancer
Prostate cancer
Scientific Papers found: Click to Expand⟱
7625- ,    Hyperthermia adds to trabectedin effectiveness and thermal enhancement is associated with BRCA2 degradation and impairment of DNA homologous recombination repair
- in-vitro, sarcoma, NA
TumCD↑, TumCCA↑, Apoptosis↑, BRCA2↓, ChemoSen↑,
735- Bor,    Boric Acid Alters the Expression of DNA Double Break Repair Genes in MCF-7-Derived Breast Cancer Stem Cells
- in-vitro, BC, NA
BRCA1↑, BRCA2↑, ATM↓,
5055- Ex,    Why exercise has a crucial role in cancer prevention, risk reduction and improved outcomes
- Review, Var, NA
OS↑, IGF-1↓, IGFBP3↑, BRCA1↑, BRCA2↑, RAS↓, P53↑, HSPs↑, Leptin↓, Irisin↓, Resistin↓, NK cell↑, CRP↓, IL6↓, TNF-α↓, PGE1↓, COX2/PTGS2↓, *GSH↑, *Catalase↑, *SOD↑, *monoA↑, *EndoR↑, *testos↑, ROS↑, QoL↑, BMD↑, BowelM↑,
7571- HPT,    Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition
- vitro+vivo, Var, NA
BRCA2↓, eff↑, RadioS↑,
7573- HPT,  Rad,    Heat-induced BRCA2 degradation in human tumours provides rationale for hyperthermia-PARP-inhibitor combination therapies
- vitro+vivo, NA, NA
RadioS↑, BRCA2↓,
7572- HPT,  Rad,    The effect of thermal dose on hyperthermia-mediated inhibition of DNA repair through homologous recombination
- in-vitro, Cerv, HeLa - in-vitro, Laryn, FaDu
RadioS↑, TumCD↑, BRCA2↓, Dose↝, BloodF↑, ROS↑, Imm↑,
7623- HPT,  Rad,    Enhancing radiosensitisation of BRCA2-proficient and BRCA2-deficient cell lines with hyperthermia and PARP1-i
- Review, Var, NA
BRCA2↓, RadioS↑, eff↑,
7626- HPT,  Rad,    Dynamics of chromosomal aberrations, induction of apoptosis, BRCA2 degradation and sensitization to radiation by hyperthermia
- in-vitro, NA, NA
BRCA2↓, selectivity↑, RadioS↑, eff↝,
7592- I3C,    Indole-3-carbinol as a chemopreventive and anti-cancer agent
- Review, Var, NA
JNK↑, STAT3↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, AhR↑, ER-α36↓, ChemoSen↑, ER Stress↑, UPR↑, BRCA1↑, BRCA2↑, TumCMig↓, TumCI↓, VEGF↓, IL8↓, MMP2↓, MMP9↓, RadioS↑, Akt↓, NF-kB↓, DR4↑, DR5↑,

Showing Research Papers: 1 to 9 of 9

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 9

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 2,  

Cell Death(tgid=5) ⓘ

AhR↑, 1,   Akt↓, 1,   Apoptosis↑, 1,   DR4↑, 1,   DR5↑, 1,   JNK↑, 1,   p27/CDKN1B↑, 1,   TumCD↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

BowelM↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSPs↑, 1,   UPR↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↓, 1,   BRCA1↑, 3,   BRCA2↓, 6,   BRCA2↑, 3,   P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↓, 1,   IGFBP3↑, 1,   RAS↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

ER-α36↓, 1,   MMP2↓, 1,   MMP9↓, 1,   TumCI↓, 1,   TumCMig↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   CRP↓, 1,   IL6↓, 1,   IL8↓, 1,   Imm↑, 1,   NF-kB↓, 1,   NK cell↑, 1,   PGE1↓, 1,   Resistin↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,   Irisin↓, 1,   Leptin↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 2,   Dose↝, 1,   eff↑, 2,   eff↝, 1,   RadioS↑, 6,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   BMD↑, 1,   BRCA1↑, 3,   CRP↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

OS↑, 1,   QoL↑, 1,  
Total Targets: 60

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GSH↑, 1,   SOD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

EndoR↑, 1,   monoA↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

testos↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: BRCA2, BReast CAncer gene 2
5 Hyperthermia
4 Radiotherapy/Radiation
1 Boron
1 Exercise
1 Indole-3-carbinol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:33  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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