Database Query Results : , , VHL

VHL, von Hippel-Lindau tumor suppressor: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
The von Hippel-Lindau (VHL) tumor suppressor gene is a critical gene involved in the regulation of cell growth and response to oxygen levels in the body.
In low oxygen conditions (hypoxia), the VHL protein is less active, allowing HIFs to accumulate and activate the transcription of genes that promote angiogenesis (formation of new blood vessels), erythropoiesis (production of red blood cells), and metabolic adaptation.
Scientific Papers found: Click to Expand⟱
1243- LA,    Lactobacilli Modulate Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway in Triple Negative Breast Cancer Cell Line
- in-vitro, BC, MDA-MB-231
Hif1a↓, HSP90↓, GLUT1↓, VHL↓, SHARP↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

SHARP↑, 1,  

Protein Folding & ER Stress ⓘ

HSP90↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   VHL↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: VHL, von Hippel-Lindau tumor suppressor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:335  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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