Database Query Results : , , vinculin

vinculin, vinculin: Click to Expand ⟱
Source:
Type:
A strong association between vinculin gene amplification and advanced prostate cancers has been documented, and knockdown of vinculin expression has been shown to reduce the growth of PC-3 cells, demonstrating that vinculin is a tumor-promoting protein.
It plays a critical role in linking the actin cytoskeleton to cell membrane adhesion complexes, thereby regulating cell shape, adhesion, and motility.

The level of vinculin expression can differ between early-stage and advanced tumors. Some studies suggest that vinculin loss may facilitate epithelial–mesenchymal transition (EMT) and distant metastasis.
 – Conversely, certain contexts document elevated vinculin expression that may support the dynamic cellular processes required for migration or survival in a specific microenvironment.

Vinculin is generally linked to a tumor-suppressive function in the context of cancer by maintaining cell–cell and cell–ECM adhesions. Altered expression or mislocalization of vinculin can lead to a loss of cell adhesion, increased migration, and enhanced invasiveness, factors that correlate with poorer clinical prognosis.


Scientific Papers found: Click to Expand⟱
4535- MAG,  5-FU,    Magnolol and 5-fluorouracil synergy inhibition of metastasis of cervical cancer cells by targeting PI3K/AKT/mTOR and EMT pathways
- in-vitro, Cerv, NA
ChemoSen↑, TumCP↓, vinculin↓, TumCA↓, TumCMig↓, TumCI↓, p‑Akt↓, p‑PI3K↓, mTOR↓, E-cadherin↑, β-catenin/ZEB1↑, Snail↓, Slug↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

p‑Akt↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,   p‑PI3K↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   Slug↓, 1,   Snail↓, 1,   TumCA↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   vinculin↓, 1,   β-catenin/ZEB1↑, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: vinculin, vinculin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:337  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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