Database Query Results : , , LAT

LAT, L-Type Amino Acid Transporter: Click to Expand ⟱
Source:
Type:
L-Type Amino Acid Transporter 1 (LAT1) mediates the uptake of essential amino acids and its expression is upregulated during the progression of several cancers. By upregulating amino acid transporters, cancer cells gain greater access to exogenous amino acids to support chronic proliferation, maintain metabolic pathways, and to enhance certain signal transduction pathways.

In many cancers it is unregulated, particularly those with high metabolic demands, LATs, especially LAT1, facilitate the uptake of essential amino acids that support protein synthesis, cell growth, and proliferation. This is typically associated with poor prognosis and aggressive tumor behavior.
Scientific Papers found: Click to Expand⟱
746- Bor,    Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope
- Review, NA, NA
eff↑, *toxicity↓, ROS↑, LAT↓, AntiCan↑, AR↓, PSMB5↓, IGF-1↓, PSA↓, TumVol↓, eff↑, Rho↓, Cdc42↓, Ca+2↓, eff↑,
3- MushShi,    AHCC Activation and Selection of Human Lymphocytes via Genotypic and Phenotypic Changes to an Adherent Cell Type: A Possible Novel Mechanism of T Cell Activation
LAT↑, FLRT2↑, GIT1↑, T-Cell↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

LAT↓, 1,   LAT↑, 1,   PSMB5↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 1,  

Migration ⓘ

Ca+2↓, 1,   Cdc42↓, 1,   FLRT2↑, 1,   GIT1↑, 1,   Rho↓, 1,  

Immune & Inflammatory Signaling ⓘ

PSA↓, 1,   T-Cell↑, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 3,  

Clinical Biomarkers ⓘ

AR↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   TumVol↓, 1,  
Total Targets: 18

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: LAT, L-Type Amino Acid Transporter
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:345  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page