Database Query Results : , , NKX3.1

NKX3.1, Homeobox protein Nkx-3.1: Click to Expand ⟱
Source:
Type:
NKX3.1 is a prostatic tumor suppressor gene located on chromosome 8p. Commonly down-regulated in human prostate cancer.
NKX3.1 is a homeobox transcription factor that is normally highly expressed in prostate luminal epithelial cells.

– During prostate tumorigenesis, NKX3.1 expression is frequently downregulated or lost, particularly in higher-grade lesions and advanced disease.
Reduced or absent NKX3.1 expression is generally associated with poor prognosis.
Loss of NKX3.1 leads to:
-Increased oxidative DNA damage
-Impaired DNA repair fidelity
-Dedifferentiation of prostate epithelium
-Increased susceptibility to oncogenic transformation (e.g., cooperation with PTEN loss)

NKX3.1 loss does not drive proliferation directly—it removes safeguards that normally restrain malignant evolution.


Scientific Papers found: Click to Expand⟱
70- QC,    Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, LAPC-4
PSA↓, AR↓, NKX3.1↓, HK2↓,
75- QC,    Quercetin targets hnRNPA1 to overcome enzalutamide resistance in prostate cancer cells
- in-vitro, Pca, HEK293 - in-vitro, NA, 22Rv1 - in-vitro, NA, C4-2B
hnRNPA1↓, PSA↓, NKX3.1↓, FKBP5↓, UBE2C↓, AR-FL↓, AR-V7↑, AR↓,
82- QC,  AG,    Arctigenin in combination with quercetin synergistically enhances the anti-proliferative effect in prostate cancer cells
- in-vitro, Pca, NA
AR↓, PI3K/Akt↓, miR-21↓, STAT3↓, BAD↓, PRAS40↓, GSK‐3β↓, PSA↓, NKX3.1↑, Bax:Bcl2↑, miR-19b↓, miR-148a↓, AMPKα↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

HK2↓, 1,   PI3K/Akt↓, 1,  

Cell Death ⓘ

BAD↓, 1,   Bax:Bcl2↑, 1,  

Kinase & Signal Transduction ⓘ

AMPKα↓, 1,  

Transcription & Epigenetics ⓘ

miR-21↓, 1,  

DNA Damage & Repair ⓘ

NKX3.1↓, 2,   NKX3.1↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

AR-FL↓, 1,   AR-V7↑, 1,   GSK‐3β↓, 1,   STAT3↓, 1,  

Migration ⓘ

hnRNPA1↓, 1,   miR-148a↓, 1,   miR-19b↓, 1,  

Immune & Inflammatory Signaling ⓘ

PSA↓, 3,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 3,   FKBP5↓, 1,  

Clinical Biomarkers ⓘ

AR↓, 3,   PSA↓, 3,  

Functional Outcomes ⓘ

PRAS40↓, 1,   UBE2C↓, 1,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: NKX3.1, Homeobox protein Nkx-3.1
3 Quercetin
1 Arctigenin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:387  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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