Database Query Results : , , UBE2C
UBE2C, Ubiquitin-conjugating enzyme E2 C: Click to Expand ⟱
| Source: |
| Type: protein/gene |
Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.
UBE2C is upregulated in 28 different cancers. UBE2C expression is significantly higher in late-stage tumors. Silencing UBE2C arrests cell cycle progression at the G 1 /S phases, inhibits cell proliferation in pancreatic ductal adenocarcinoma and blocks the G 2 /M transition in melanoma.
UBE2C is most frequently overexpressed in a wide array of cancers compared to their normal tissue counterparts.
– High UBE2C expression is consistently associated with aggressive tumor features, advanced disease, and reduced overall survival.
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Scientific Papers found: Click to Expand⟱
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in-vitro, |
Pca, |
HEK293 |
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- |
in-vitro, |
NA, |
22Rv1 |
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- |
in-vitro, |
NA, |
C4-2B |
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hnRNPA1↓, PSA↓, NKX3.1↓, FKBP5↓, UBE2C↓, AR-FL↓, AR-V7↑, AR↓,
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
DNA Damage & Repair ⓘ
NKX3.1↓, 1,
Proliferation, Differentiation & Cell State ⓘ
AR-FL↓, 1, AR-V7↑, 1,
Migration ⓘ
hnRNPA1↓, 1,
Immune & Inflammatory Signaling ⓘ
PSA↓, 1,
Hormonal & Nuclear Receptors ⓘ
AR↓, 1, FKBP5↓, 1,
Clinical Biomarkers ⓘ
AR↓, 1, PSA↓, 1,
Functional Outcomes ⓘ
UBE2C↓, 1,
Total Targets: 10
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: UBE2C, Ubiquitin-conjugating enzyme E2 C
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:391 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid
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