Database Query Results : , , DNA-PK

DNA-PK, DNA-dependent protein kinase: Click to Expand ⟱
Source:
Type:
DNA-dependent protein kinase catalytic subunit (DNA-PK) is a pleiotropic kinase involved in DNA repair and transcriptional regulation. DNA-PK is deregulated in selected cancer types and is strongly associated with poor outcome.

Elevated levels of DNA-PK have been observed in various cancers, including breast cancer, lung cancer, and liver cancer. High expression levels are often associated with aggressive tumor characteristics and poor prognosis.
Conversely, low expression of DNA-PK may be linked to increased sensitivity to certain therapies, particularly those that induce DNA damage, such as radiation and some chemotherapeutic agents.
Scientific Papers found: Click to Expand⟱
234- AL,    Allicin Induces Anti-human Liver Cancer Cells through the p53 Gene Modulating Apoptosis and Autophagy
- in-vitro, HCC, Hep3B
ROS↑, *toxicity∅, MMP↓, BAX↑, Bcl-2↓, AIF↑, Casp3↑, Casp8↑, Casp9↑, eff↓, γH2AX↑, selectivity↑, DNA-PK↑,
1361- Ash,  SRF,    Withaferin A, a natural thioredoxin reductase 1 (TrxR1) inhibitor, synergistically enhances the antitumor efficacy of sorafenib through ROS-mediated ER stress and DNA damage in hepatocellular carcinoma cells
- in-vitro, Liver, HUH7 - in-vivo, Liver, HUH7
TrxR↓, ROS↑, DNA-PK↑, ER Stress↑, Apoptosis↑, eff↓,
1978- CUR,    Curcumin targeting the thioredoxin system elevates oxidative stress in HeLa cells
- in-vitro, Cerv, HeLa
TrxR1↓, ROS↑, DNA-PK↑, eff↑, Trx↓, Trx1↓,
1864- DCA,  MET,    Dichloroacetate Enhances Apoptotic Cell Death via Oxidative Damage and Attenuates Lactate Production in Metformin-Treated Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, T47D - in-vitro, Nor, MCF10
PDKs↓, eff↑, ROS↑, PDK1↓, lactateProd↓, p‑PDH↑, Dose∅, OCR↑, DNA-PK↑, γH2AX↑, cl‑PARP↑, selectivity↑, *toxicity∅,
76- QC,    Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy
- in-vitro, Pca, PC3
aSmase↝, Diablo↝, Fas↝, Hsc70↝, Hif1a↝, Mcl-1↝, HSP90↝, FLT4↝, EphB4↝, DNA-PK↝, PARP1↝, ATM↝, XIAP↝, PLC↝, GnT-V↝, heparanase↝, NM23↝, CSR1↝, SPP1↝, DNMT1↝, HDAC4↝, CXCR4↝, β-catenin/ZEB1↝, FBXW7↝, AMACR↝, cycD1/CCND1↝, IGF-1R↝, IMPDH1↝, IMPDH2↝, HEC1↝, NHE1↝, NOS2↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 4,   Trx↓, 1,   Trx1↓, 1,   TrxR↓, 1,   TrxR1↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   MMP↓, 1,   OCR↑, 1,   XIAP↝, 1,  

Core Metabolism/Glycolysis ⓘ

AMACR↝, 1,   lactateProd↓, 1,   p‑PDH↑, 1,   PDK1↓, 1,   PDKs↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   aSmase↝, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   CSR1↝, 1,   Diablo↝, 1,   Fas↝, 1,   Mcl-1↝, 1,  

Transcription & Epigenetics ⓘ

SPP1↝, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,   Hsc70↝, 1,   HSP90↝, 1,  

DNA Damage & Repair ⓘ

ATM↝, 1,   DNA-PK↑, 4,   DNA-PK↝, 1,   DNMT1↝, 1,   cl‑PARP↑, 1,   PARP1↝, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

FBXW7↝, 1,   HDAC4↝, 1,   IGF-1R↝, 1,  

Migration ⓘ

EphB4↝, 1,   GnT-V↝, 1,   heparanase↝, 1,   NM23↝, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature ⓘ

FLT4↝, 1,   Hif1a↝, 1,  

Barriers & Transport ⓘ

NHE1↝, 1,  

Immune & Inflammatory Signaling ⓘ

CXCR4↝, 1,  

Cellular Microenvironment ⓘ

PLC↝, 1,  

Drug Metabolism & Resistance ⓘ

Dose∅, 1,   eff↓, 2,   eff↑, 2,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

HEC1↝, 1,   NOS2↝, 1,  

Functional Outcomes ⓘ

IMPDH1↝, 1,   IMPDH2↝, 1,  
Total Targets: 58

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity∅, 2,  
Total Targets: 1

Scientific Paper Hit Count for: DNA-PK, DNA-dependent protein kinase
1 Allicin (mainly Garlic)
1 Ashwagandha(Withaferin A)
1 Sorafenib (brand name Nexavar)
1 Curcumin
1 Dichloroacetate
1 Metformin
1 Quercetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:399  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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