Database Query Results : , , GnT-V

GnT-V, N-acetylglucosaminyltransferase-V: Click to Expand ⟱
Source:
Type:
Activity of glycosyltransferase GnT-V correlates with cancer malignancy and poor prognosis. GnT-V, or N-acetylglucosaminyltransferase V (also known as MGAT5), is an enzyme involved in the glycosylation of proteins, specifically in the addition of N-acetylglucosamine (GlcNAc) residues to the core structure of N-glycans. This enzyme plays a significant role in the modification of glycoproteins, which can influence various cellular processes, including cell adhesion, signaling, and immune response.

GnT-V expression is often elevated in various cancers and is generally associated with poorer prognosis due to its role in promoting tumor aggressiveness and metastasis. Its involvement in glycosylation processes can influence cell behavior, including adhesion and migration, which are critical for cancer progression.
Scientific Papers found: Click to Expand⟱
76- QC,    Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy
- in-vitro, Pca, PC3
aSmase↝, Diablo↝, Fas↝, Hsc70↝, Hif1a↝, Mcl-1↝, HSP90↝, FLT4↝, EphB4↝, DNA-PK↝, PARP1↝, ATM↝, XIAP↝, PLC↝, GnT-V↝, heparanase↝, NM23↝, CSR1↝, SPP1↝, DNMT1↝, HDAC4↝, CXCR4↝, β-catenin/ZEB1↝, FBXW7↝, AMACR↝, cycD1/CCND1↝, IGF-1R↝, IMPDH1↝, IMPDH2↝, HEC1↝, NHE1↝, NOS2↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

XIAP↝, 1,  

Core Metabolism/Glycolysis ⓘ

AMACR↝, 1,  

Cell Death ⓘ

aSmase↝, 1,   CSR1↝, 1,   Diablo↝, 1,   Fas↝, 1,   Mcl-1↝, 1,  

Transcription & Epigenetics ⓘ

SPP1↝, 1,  

Protein Folding & ER Stress ⓘ

Hsc70↝, 1,   HSP90↝, 1,  

DNA Damage & Repair ⓘ

ATM↝, 1,   DNA-PK↝, 1,   DNMT1↝, 1,   PARP1↝, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

FBXW7↝, 1,   HDAC4↝, 1,   IGF-1R↝, 1,  

Migration ⓘ

EphB4↝, 1,   GnT-V↝, 1,   heparanase↝, 1,   NM23↝, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature ⓘ

FLT4↝, 1,   Hif1a↝, 1,  

Barriers & Transport ⓘ

NHE1↝, 1,  

Immune & Inflammatory Signaling ⓘ

CXCR4↝, 1,  

Cellular Microenvironment ⓘ

PLC↝, 1,  

Clinical Biomarkers ⓘ

HEC1↝, 1,   NOS2↝, 1,  

Functional Outcomes ⓘ

IMPDH1↝, 1,   IMPDH2↝, 1,  
Total Targets: 32

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: GnT-V, N-acetylglucosaminyltransferase-V
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:402  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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