Database Query Results : , , HEC1

HEC1, highly expressed in cancer 1: Click to Expand ⟱
Source:
Type:
HEC1 (also known as HEC1 or NDC80) is a protein that is part of the NDC80 complex, which is crucial for the proper functioning of the mitotic spindle during cell division. It plays a significant role in the attachment of microtubules to kinetochores, ensuring accurate chromosome segregation during mitosis. Dysregulation of HEC1 has been implicated in various cancers, and its expression levels can have prognostic implications.
Hec1 is often overexpressed in cancers with poor prognosis.
Hec1 is significantly upregulated in cervical cancer tissues and associated with poor prognosis in cervical cancer patients.

Its overexpression is associated with various cancers, including breast, lung, ovarian, and colorectal cancers, often correlating with poor prognosis and aggressive tumor behavior. While HEC1 itself is not classified as a traditional oncogene, its dysregulation contributes to oncogenic processes, making it a potential target for therapeutic intervention and a candidate biomarker for cancer prognosis.
Scientific Papers found: Click to Expand⟱
76- QC,    Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy
- in-vitro, Pca, PC3
aSmase↝, Diablo↝, Fas↝, Hsc70↝, Hif1a↝, Mcl-1↝, HSP90↝, FLT4↝, EphB4↝, DNA-PK↝, PARP1↝, ATM↝, XIAP↝, PLC↝, GnT-V↝, heparanase↝, NM23↝, CSR1↝, SPP1↝, DNMT1↝, HDAC4↝, CXCR4↝, β-catenin/ZEB1↝, FBXW7↝, AMACR↝, cycD1/CCND1↝, IGF-1R↝, IMPDH1↝, IMPDH2↝, HEC1↝, NHE1↝, NOS2↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

XIAP↝, 1,  

Core Metabolism/Glycolysis ⓘ

AMACR↝, 1,  

Cell Death ⓘ

aSmase↝, 1,   CSR1↝, 1,   Diablo↝, 1,   Fas↝, 1,   Mcl-1↝, 1,  

Transcription & Epigenetics ⓘ

SPP1↝, 1,  

Protein Folding & ER Stress ⓘ

Hsc70↝, 1,   HSP90↝, 1,  

DNA Damage & Repair ⓘ

ATM↝, 1,   DNA-PK↝, 1,   DNMT1↝, 1,   PARP1↝, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

FBXW7↝, 1,   HDAC4↝, 1,   IGF-1R↝, 1,  

Migration ⓘ

EphB4↝, 1,   GnT-V↝, 1,   heparanase↝, 1,   NM23↝, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature ⓘ

FLT4↝, 1,   Hif1a↝, 1,  

Barriers & Transport ⓘ

NHE1↝, 1,  

Immune & Inflammatory Signaling ⓘ

CXCR4↝, 1,  

Cellular Microenvironment ⓘ

PLC↝, 1,  

Clinical Biomarkers ⓘ

HEC1↝, 1,   NOS2↝, 1,  

Functional Outcomes ⓘ

IMPDH1↝, 1,   IMPDH2↝, 1,  
Total Targets: 32

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HEC1, highly expressed in cancer 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:412  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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