Database Query Results : , , IGF-2

IGF-2, Insulin-like growth factor 2: Click to Expand ⟱
Source:
Type: Oncogene
Insulin-like Growth Factor 2 (IGF-2) is a protein that plays a significant role in growth and development, particularly during fetal development. It is part of the insulin-like growth factor (IGF) family, which includes IGF-1 and IGF-2, and is involved in cellular growth, differentiation, and survival.
-IGF2 is a mitogenic polypeptide that is abundantly expressed in the brain, especially in the cortex and hippocampus, and is required for memory consolidation and enhancement.

IGF-2 is often overexpressed in various human cancers because the dysregulation of the differentially methylated region (DMR) on the maternal chromosome causes loss of imprinting (LOI).

Oncogenic Potential:
IGF-2 is considered an oncogene due to its role in promoting cell proliferation and survival. It activates signaling pathways such as the PI3K/Akt and MAPK pathways, which are critical for cell growth and survival.
The overexpression of IGF-2 can lead to increased tumor cell proliferation, invasion, and metastasis.
High levels of IGF-2 expression are often associated with a poor prognosis in various cancers.


Scientific Papers found: Click to Expand⟱
5064- Ex,    Effect Of Exercise Intervention On Insulin, Igfs And Igfbps In Cancer Patients
- Review, Var, NA
IGF-1↓, IGF-2↓, Insulin↓,
5061- Ex,    Role of physical exercise in modulating the insulin-like growth factor system for improving breast cancer outcomes: A meta-analysis
- Review, BC, NA
IGF-2↓, IGFBP1↓, HOMA↓, glucose∅, IGF-1∅, eff↑,
2039- PB,    TXNIP mediates the differential responses of A549 cells to sodium butyrate and sodium 4‐phenylbutyrate treatment
- in-vitro, Lung, A549 - in-vitro, Nor, HEK293
TXNIP↑, Casp3↑, Casp7↑, mt-ROS↑, GlucoseCon↓, TumCP↓, TumCD↑, IGF-2↑, HDAC↓, ROS⇅,
78- QC,    Effects of quercetin on insulin-like growth factors (IGFs) and their binding protein-3 (IGFBP-3) secretion and induction of apoptosis in human prostate cancer cells
- in-vitro, Pca, PC3
IGF-1↓, IGF-2↓, IGFBP3↑, Bcl-2↓, Bcl-xL↓, Casp3↑, Apoptosis↑, BAX↑, DNAdam↑,
86- QC,  PacT,    Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3)
- vitro+vivo, Pca, PC3
BAD↑, IGFBP3↑, Cyt‑c↑, cl‑Casp9↑, Casp10↑, cl‑PARP↑, Casp3↑, IGF-1R↓, PI3K↓, p‑Akt↓, cycD1/CCND1↓, IGF-1↓, IGF-2↓, IGF-1R↓, MMP↓, Apoptosis↑, NA?,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

HOMA↓, 1,   NA?, 1,  

Redox & Oxidative Stress ⓘ

ROS⇅, 1,   mt-ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

Insulin↓, 1,   MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

glucose∅, 1,   GlucoseCon↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Apoptosis↑, 2,   BAD↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   Casp10↑, 1,   Casp3↑, 3,   Casp7↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,   TumCD↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,   IGF-1↓, 3,   IGF-1∅, 1,   IGF-1R↓, 2,   IGF-2↓, 4,   IGF-2↑, 1,   IGFBP1↓, 1,   IGFBP3↑, 2,   PI3K↓, 1,  

Migration ⓘ

TumCP↓, 1,   TXNIP↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 35

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: IGF-2, Insulin-like growth factor 2
2 Exercise
2 Quercetin
1 Phenylbutyrate
1 Paclitaxel
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:416  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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