Database Query Results : , , LAMA5

LAMA5, laminin alpha 5: Click to Expand ⟱
Source:
Type: gene
The LAMA5 gene is a gene that encodes for the laminin alpha 5 chain, a protein that is part of the laminin family. Laminins are high-molecular weight glycoproteins that are a major component of the basement membrane, a layer of tissue that separates epithelial cells from the underlying connective tissue.
Overexpressed in: Breast, lung, CRC, Prostate
Scientific Papers found: Click to Expand⟱
733- Bor,    The analysis of boric acid effect on epithelial-mesenchymal transition of CD133 + CD117 + lung cancer stem cells
- in-vitro, Lung, NA
Snail↑, ITGB1↑, ITGA5↑, COL1A1↓, LAMA5↑, MMP3↓, Vim↓, E-cadherin↑, EMT↓, Zeb1↑,
756- Bor,    Evaluation of Boric Acid Treatment on microRNA‐127‐5p and Metastasis Genes Orchestration of Breast Cancer Stem Cells
- in-vitro, BC, MCF-7
COL1A1↓, Vim↓, miR-127-5p↑, Zeb1↑, CDH1↑, ITGB1↑, ITGA5↑, LAMA5↑, Snail↑,
736- Bor,    Evaluation of Boric Acid Treatment on microRNA-127-5p and Metastasis Genes Orchestration of Breast Cancer Stem Cells
- in-vitro, BC, MCF-7
miR-126↑, COL1A1↓, Vim↓, Zeb1↑, CDH1↑, ITGB1↑, ITGA5↑, LAMA5↑, Snail↑, miR-127-5p↑,
439- CUR,    Curcumin suppresses LGR5(+) colorectal cancer stem cells by inducing autophagy and via repressing TFAP2A-mediated ECM pathway
- in-vitro, CRC, LGR5
Apoptosis↑, TumAuto↑, GP1BB↓, COL9A3↓, COMP↓, AGRN↓, ITGB4↓, LAMA5↓, COL2A1↓, ITGB6↓, LGR5↓, TFAP2A↓, ECM/TCF↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Apoptosis↑, 1,   miR-127-5p↑, 2,  

Transcription & Epigenetics ⓘ

COMP↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

Cell Cycle & Senescence ⓘ

TFAP2A↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   LGR5↓, 1,  

Migration ⓘ

AGRN↓, 1,   CDH1↑, 2,   COL1A1↓, 3,   COL2A1↓, 1,   COL9A3↓, 1,   E-cadherin↑, 1,   GP1BB↓, 1,   ITGA5↑, 3,   ITGB1↑, 3,   ITGB4↓, 1,   ITGB6↓, 1,   LAMA5↓, 1,   LAMA5↑, 3,   MMP3↓, 1,   Snail↑, 3,   Vim↓, 3,   Zeb1↑, 3,  

Angiogenesis & Vasculature ⓘ

ECM/TCF↓, 1,   miR-126↑, 1,  
Total Targets: 26

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: LAMA5, laminin alpha 5
3 Boron
1 Curcumin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:423  State#:%  Dir#:%
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