Database Query Results : , , BAD
BAD, BCL2 associated agonist of cell death: Click to Expand ⟱
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BCL2 associated agonist of cell death (BAD) protein is a pro-apoptotic member of the Bcl-2 gene family.
Expression of the BAD is associated with the development and progression of cancer.
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Scientific Papers found: Click to Expand⟱
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in-vitro, |
Lung, |
H1650 |
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in-vitro, |
Lung, |
A549 |
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in-vitro, |
CRC, |
HCT116 |
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in-vitro, |
BC, |
MDA-MB-231 |
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in-vivo, |
NA, |
NA |
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PD-L1↑, eff↓, ROS↑, ER Stress↑, Apoptosis↑, BAX↑, Bak↑, BAD↑, Bcl-2↓, XIAP↓, survivin↓, cl‑PARP↑, CHOP↑, p‑eIF2α↑, ICD↑, eff↑,
TumCP↓, TumCMig↓, ROS↑, Apoptosis↑, BAX↑, BAD↑, Bak↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, E-cadherin↑, TIMP1↑, γH2AX↑, Bcl-2↓, N-cadherin↓, Vim↓, Snail↓, RAD51↓, PCNA↓,
tumCV↓, DNAdam↑, Casp3↑, Casp7↑, FasL↑, Casp8↑, Casp9↑, PARP↑, BAX↑, BAD↑, APAF1↑, MMP2↓, MMP9↓, p‑p38↑, ERK↑, MAPK↑,
PI3K↓, p‑Akt↓, ROS↑, TumCCA↑, p27↑, P21↑, mt-Apoptosis↑, BAD↑, Casp9↑, MMP↓, eff↓,
tumCV↓, BAX↑, BID↑, BOK↑, APAF1↑, TNF-α↑, FasL↑, Fas↑, FADD↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Mcl-1↓, NAIP↓, Bcl-2↓, CDK4↓, CycB/CCNB1↓, cycD1/CCND1↓, cycE1↓, TRAIL↑, p‑Akt↓, Akt↓, mTOR↓, PDK1↓, BAD↓, GSK‐3β↑, AMPK↑, p27↑, P53↑,
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in-vitro, |
AD, |
HT22 |
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in-vivo, |
AD, |
NA |
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*ROS↓, *Ca+2↓, *BAX↓, *BAD↓, *Casp3↓, *cognitive↑, *memory↑, *Aβ↓, *GPx↑, *SOD↑, *ChAT↑, *Ach↑, *AChE↓, *ROS↓, *p‑Akt↑, *p‑mTOR↑, *neuroP↑,
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in-vitro, |
Pca, |
DU145 |
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in-vitro, |
Pca, |
PC3 |
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BAD↝, BAX↝, eff↑,
14-3-3 proteins↓, p‑BAD↓, p‑Akt↓, Akt↓, cl‑Casp9↑, cl‑PARP↑,
Apoptosis↑, TumCCA↑, p‑Akt↓, Akt↓, Bcl-2↓, p‑BAD↓, BAD↑, cl‑PARP↑, ROS↑, HSP27↑, Beclin-1↑, p62↑, GPx1↓, GPx4↓,
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in-vitro, |
Pca, |
PC3 |
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in-vitro, |
Pca, |
LNCaP |
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in-vivo, |
NA, |
NA |
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SDC1↑, p‑PCK1↓, Akt↓, BAD↓,
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in-vitro, |
HCC, |
NA |
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in-vivo, |
NA, |
NA |
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PFK↓, Glycolysis↓, lactateProd↓, GlucoseCon↓, TumCP↓, TumCCA↑, Casp3↑, cl‑PARP↑, Apoptosis↑, Casp8↑, Casp9↑, Cyt‑c↝, MMP↓, BAD↑, GLUT2↓, PKM2∅,
BAD↓, PARP↑, Casp7↑, IκB↓, Ki-67↓, VEGF↓, EGFR↓, FGF↓, TGF-β↓, TNF-α↓, SCF↓, Bax:Bcl2↑, NF-kB↓,
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Review, |
Var, |
NA |
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Review, |
AD, |
NA |
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Beclin-1↑, ROS↑, Apoptosis↑, ER Stress↑, *Inflam↓, *cardioP↑, *antiOx↑, *LDL↓, *NF-kB↓, *MPO↓, *glucose↓, *ROS↓, ATG5↑, LC3B↑, MMP↑, lactateProd↓, VEGF↓, Zeb1↑, Wnt↑, IGF-1R↑, Fas↑, Bak↑, BAD↑, TP53↓, Myc↓, Casp8↓, LC3II↑, NOTCH3↓, eff↑, p‑Akt↓, PARP↑, *Cyt‑c↓, *BAX↓, *memory↑, *neuroP↑, *Ca+2?, GRP78/BiP↑, CHOP↑, ATF4↑, Casp3↑, Casp8↑, UPR↑,
tumCV↓, Apoptosis↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, BAD↑, Bcl-2↓, Bcl-xL↓, PI3K↓, Akt↓, ERK↓, p‑JNK↑, p‑cJun↑, p‑p38↑, ROS↑, MMP↓, mTORC1↓, PTEN↑, p‑GSK‐3β↓, GSK‐3β↑, NF-kB↓, IKKα↑, Cyt‑c↑,
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, eff↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
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in-vitro, |
Melanoma, |
U266 |
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TumCD↑, TumCCA↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, p‑Akt↓, p‑mTOR↓, ROS↑, eff↓,
COX2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP↑, eff↑, ChemoSen↑,
TumCP↓, TumCCA↑, cycA1/CCNA1↓, ROS↑, P21↑, CDK2↓, CDK1↓, CDC25↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Cyt‑c↑,
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1↓, Hif1a↓, LC3II↑, Beclin-1↑,
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiAg↑, *BBB↑, *BioAv↓, BAD↑, Casp3↑, Casp6↑, Casp9↑, JNK↑, Bcl-xL↓, PTEN↑, Akt↓, NF-kB↓, MMP7↓, MMP9↓, uPA↓, Hif1a↓, VEGF↓, FOXO3↓, Ca+2↑, TumCCA↑, ROS↑, Cyt‑c↑,
TumCP↓, p‑CHK1↓, Ca+2↑, Casp3↓, Casp7↓, p‑BAD↓, ChemoSen↑,
*BAD↓, *BAX↓, *Casp3↓, *Bcl-xL↑, *p‑Akt↑, *MMP9↓, *p‑ERK↑, *HIF-1↓, *ROS↓, *VEGF↑, *Ca+2↓, *SOD↑, *IL2↑, *p38↑, *HSP70/HSPA5↑, *Apoptosis↓, *ROS↓, *NO↓,
TumCCA↑, Apoptosis↑, ER Stress↑, UPR↑, CHOP↑, ROS↑, Bcl-2↓, NOX4↑, Hif1a↓, MMP2↓, MMP↓, VEGF↓, Akt↓, NF-kB↓, p65↓, SIRT3↓, mTOR↓, Catalase↓, SOD2↓, FASN↓, STAT3↓, HDAC2↓, HDAC3↓, BAD↑, BAX↑, Bak↑, Casp3↑, Casp9↑, PARP↑, P53↑, P21↑, p27↑, Half-Life↝, BioAv↓, BioAv↓, selectivity↑, RadioS↑, *ROS↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *chemoP↑, *Inflam↓, PPARγ↑,
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in-vitro, |
Pca, |
LNCaP |
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in-vitro, |
Pca, |
PrEC |
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in-vitro, |
Pca, |
YPEN-1 |
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in-vitro, |
Pca, |
HCT116 |
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Casp8↑, Casp9↑, PARP↑, BAD↓, BAX↑, PI3K/Akt↓,
BAD↑, IGFBP3↑, Cyt‑c↑, cl‑Casp9↑, Casp10↑, cl‑PARP↑, Casp3↑, IGF-1R↓, PI3K↓, p‑Akt↓, cycD1/CCND1↓, IGF-1↓, IGF-2↓, IGF-1R↓,
AR↓, PI3K/Akt↓, miR-21↓, STAT3↓, BAD↓, PRAS40↓, GSK‐3β↓, PSA↓, NKX3.1↑, Bax:Bcl2↑, miR-19b↓, miR-148a↓, AMPKα↓,
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in-vitro, |
HNSCC, |
HaCaT |
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in-vivo, |
NA, |
NA |
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GSDME-N↑, Pyro↑, cMyc↓, HK2↓, BAD↑, BAX↑, Casp3↑, NRF2↓, xCT↓, ROS↑, eff↑, Glycolysis↓, GlucoseCon↓, lactateProd↓, ATP↓, xCT↓, eff↑,
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 27
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
Catalase↓, 1, GPx1↓, 1, GPx4↓, 1, GSTs↓, 1, HO-1↑, 1, ICD↑, 1, NOX4↑, 1, NRF2↓, 2, ROS↑, 14, SIRT3↓, 1, SOD↓, 1, SOD2↓, 1, xCT↓, 2,
Metal & Cofactor Biology ⓘ
IronCh↑, 1,
Mitochondria & Bioenergetics ⓘ
ATP↓, 1, BOK↑, 2, CDC2↓, 1, CDC25↓, 2, EGF↓, 1, MEK↓, 1, MMP↓, 7, MMP↑, 1, mtDam↑, 1, XIAP↓, 2,
Core Metabolism/Glycolysis ⓘ
ACC↑, 3, AKT1↓, 1, AMPK↑, 3, cMyc↓, 2, FASN↓, 1, GlucoseCon↓, 2, GLUT2↓, 1, Glycolysis↓, 2, HK2↓, 1, lactateProd↓, 3, p‑PCK1↓, 1, PDK1↓, 1, PFK↓, 1, PI3K/Akt↓, 2, PKM2∅, 1, PPARγ↑, 1,
Cell Death ⓘ
14-3-3 proteins↓, 1, Akt↓, 9, Akt↑, 1, p‑Akt↓, 7, APAF1↑, 2, Apoptosis↑, 8, mt-Apoptosis↑, 1, BAD↓, 5, BAD↑, 17, BAD↝, 1, p‑BAD↓, 3, Bak↑, 4, BAX↑, 13, BAX↝, 1, Bax:Bcl2↑, 2, Bcl-2↓, 11, Bcl-xL↓, 3, BID↑, 2, BIM↑, 3, Casp10↑, 1, cl‑Casp12↑, 1, Casp3↓, 1, Casp3↑, 13, cl‑Casp3↑, 1, Casp6↑, 1, Casp7↓, 1, Casp7↑, 3, Casp8↓, 1, Casp8↑, 6, cl‑Casp8↑, 1, Casp9↑, 9, cl‑Casp9↑, 3, Cyt‑c↑, 8, Cyt‑c↝, 1, Diablo↑, 2, DR5↑, 2, FADD↑, 2, Fas↑, 4, FasL↑, 2, GSDME-N↑, 1, hTERT/TERT↓, 1, JNK↑, 1, p‑JNK↑, 1, MAPK↓, 1, MAPK↑, 1, Mcl-1↓, 5, Myc↓, 2, NAIP↓, 2, p27↑, 3, p38↓, 1, p‑p38↑, 2, Pyro↑, 1, survivin↓, 1, Telomerase↓, 1, TRAIL↑, 2, TumCD↑, 1,
Kinase & Signal Transduction ⓘ
AMPKα↓, 1,
Transcription & Epigenetics ⓘ
cJun↓, 2, p‑cJun↑, 1, miR-21↓, 1, tumCV↓, 3,
Protein Folding & ER Stress ⓘ
CHOP↑, 4, eIF2α↑, 1, p‑eIF2α↑, 1, ER Stress↑, 4, GRP78/BiP↑, 1, HSP27↓, 1, HSP27↑, 1, HSP70/HSPA5↓, 2, PERK↑, 1, UPR↑, 2,
Autophagy & Lysosomes ⓘ
ATG5↑, 1, Beclin-1↑, 3, LC3B↑, 1, LC3II↑, 2, p62↑, 1,
DNA Damage & Repair ⓘ
p‑CHK1↓, 1, DNAdam↑, 3, NKX3.1↑, 1, P53↑, 3, PARP↑, 5, cl‑PARP↑, 7, PCNA↓, 1, RAD51↓, 1, TP53↓, 1, γH2AX↑, 1,
Cell Cycle & Senescence ⓘ
CDK1↓, 1, CDK2↓, 4, CDK4↓, 4, cycA1/CCNA1↓, 2, CycB/CCNB1↓, 1, cycD1/CCND1↓, 4, cycE1↓, 1, P21↑, 4, Securin↓, 1, TumCCA↑, 9,
Proliferation, Differentiation & Cell State ⓘ
cFos↓, 2, EMT↓, 2, ERK↓, 1, ERK↑, 1, p‑ERK↓, 1, FGF↓, 1, FOXO3↓, 1, GSK‐3β↓, 1, GSK‐3β↑, 2, p‑GSK‐3β↓, 1, HDAC2↓, 1, HDAC3↓, 1, IGF-1↓, 1, IGF-1R↓, 2, IGF-1R↑, 1, IGF-2↓, 1, IGFBP3↑, 1, mTOR↓, 4, p‑mTOR↓, 1, mTORC1↓, 1, NOTCH3↓, 1, PI3K↓, 5, PTEN↑, 2, SCF↓, 1, STAT3↓, 2, TCF↑, 1, Wnt↓, 2, Wnt↑, 1,
Migration ⓘ
Akt2↓, 1, Ca+2↑, 3, E-cadherin↓, 1, E-cadherin↑, 3, Fibronectin↓, 2, Ki-67↓, 1, MET↓, 1, miR-148a↓, 1, miR-19b↓, 1, MMP1↓, 1, MMP2↓, 4, MMP3↓, 1, MMP7↓, 2, MMP9↓, 3, N-cadherin↓, 4, SDC1↑, 1, Snail↓, 3, TGF-β↓, 1, TIMP1↑, 1, TumCMig↓, 1, TumCP↓, 5, TumMeta↓, 1, Twist↓, 1, uPA↓, 3, Vim↓, 4, Zeb1↓, 1, Zeb1↑, 1, β-catenin/ZEB1↓, 1,
Angiogenesis & Vasculature ⓘ
angioG↓, 2, ATF4↓, 1, ATF4↑, 2, EGFR↓, 3, eNOS↓, 1, Hif1a↓, 3, VEGF↓, 5,
Immune & Inflammatory Signaling ⓘ
COX2↓, 2, IKKα↑, 1, IκB↓, 1, NF-kB↓, 7, NF-kB↑, 1, p65↓, 2, PD-L1↑, 1, PGE2↓, 1, PSA↓, 1, TNF-α↓, 1, TNF-α↑, 1,
Hormonal & Nuclear Receptors ⓘ
AR↓, 1,
Drug Metabolism & Resistance ⓘ
BioAv↓, 2, ChemoSen↑, 3, eff↓, 3, eff↑, 7, Half-Life↝, 1, RadioS↑, 1, selectivity↑, 1,
Clinical Biomarkers ⓘ
AR↓, 1, EGFR↓, 3, hTERT/TERT↓, 1, Ki-67↓, 1, Myc↓, 2, PD-L1↑, 1, PSA↓, 1, TP53↓, 1,
Functional Outcomes ⓘ
PRAS40↓, 1,
Total Targets: 227
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
antiOx↑, 3, Catalase↑, 1, GPx↑, 1, GSH↑, 2, MDA↓, 1, MPO↓, 1, NRF2↑, 2, ROS↓, 7, SOD↑, 4,
Core Metabolism/Glycolysis ⓘ
glucose↓, 1, LDHA↑, 1, LDL↓, 1,
Cell Death ⓘ
p‑Akt↑, 2, Apoptosis↓, 1, BAD↓, 2, BAX↓, 3, Bcl-xL↑, 1, Casp3↓, 2, Cyt‑c↓, 1, p38↑, 1,
Transcription & Epigenetics ⓘ
Ach↑, 1,
Protein Folding & ER Stress ⓘ
HSP70/HSPA5↑, 1,
Autophagy & Lysosomes ⓘ
Beclin-1↓, 1,
Proliferation, Differentiation & Cell State ⓘ
p‑ERK↑, 1, p‑mTOR↑, 1,
Migration ⓘ
AntiAg↑, 1, Ca+2?, 1, Ca+2↓, 2, MMP9↓, 1,
Angiogenesis & Vasculature ⓘ
HIF-1↓, 1, NO↓, 1, VEGF↑, 1,
Barriers & Transport ⓘ
BBB↑, 1,
Immune & Inflammatory Signaling ⓘ
IL2↑, 1, Inflam↓, 3, NF-kB↓, 1,
Synaptic & Neurotransmission ⓘ
AChE↓, 1, ChAT↑, 1,
Protein Aggregation ⓘ
Aβ↓, 1,
Drug Metabolism & Resistance ⓘ
BioAv↓, 2,
Functional Outcomes ⓘ
cardioP↑, 1, chemoP↑, 1, cognitive↑, 1, memory↑, 2, neuroP↑, 4,
Infection & Microbiome ⓘ
Bacteria↓, 1,
Total Targets: 46
Scientific Paper Hit Count for: BAD, BCL2 associated agonist of cell death
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:426 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid
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