Database Query Results : , , PRAS40

PRAS40, proline-rich Akt substrate of 40 kDa: Click to Expand ⟱
Source:
Type:
The phosphorylation of PRAS40 is often associated with the tumor progression of melanoma, prostate cancer, etc. Elevated PRAS40-Thr 246 phosphorylation has been reported in several cancer cell lines.

PRAS40 serves as an important mediator linking Akt signaling to mTORC1 activation. In many cancers—such as breast, lung, and colorectal—enhanced Akt activity leads to increased phosphorylation of PRAS40, thereby promoting tumor cell survival, proliferation, and growth. These changes are often associated with more aggressive tumor behavior and poorer outcomes.
Scientific Papers found: Click to Expand⟱
82- QC,  AG,    Arctigenin in combination with quercetin synergistically enhances the anti-proliferative effect in prostate cancer cells
- in-vitro, Pca, NA
AR↓, PI3K/Akt↓, miR-21↓, STAT3↓, BAD↓, PRAS40↓, GSK‐3β↓, PSA↓, NKX3.1↑, Bax:Bcl2↑, miR-19b↓, miR-148a↓, AMPKα↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

PI3K/Akt↓, 1,  

Cell Death ⓘ

BAD↓, 1,   Bax:Bcl2↑, 1,  

Kinase & Signal Transduction ⓘ

AMPKα↓, 1,  

Transcription & Epigenetics ⓘ

miR-21↓, 1,  

DNA Damage & Repair ⓘ

NKX3.1↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↓, 1,   STAT3↓, 1,  

Migration ⓘ

miR-148a↓, 1,   miR-19b↓, 1,  

Immune & Inflammatory Signaling ⓘ

PSA↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

PRAS40↓, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PRAS40, proline-rich Akt substrate of 40 kDa
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:427  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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