Database Query Results : , , TAp63α

TAp63α, TAp63α: Click to Expand ⟱
Source:
Type:
TAp63α is a protein isoform of the p63 gene, which is a member of the p53 family of transcription factors. p63 is involved in various cellular processes, including development, cell cycle regulation, and apoptosis.

TAp63α has been implicated in cancer development and progression. It is often overexpressed in various types of cancer, including breast, lung, and head and neck cancers. The overexpression of TAp63α has been associated with poor prognosis and aggressive tumor behavior.

In multiple cancers, lower expression of the tumor‐suppressive TAp63α isoform tends to correlate with a more aggressive clinical course and poorer overall survival.
Scientific Papers found: Click to Expand⟱
168- CUR,    Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism
- in-vitro, Pca, PC3
Akt↓, mTOR↓, AMPK↑, TAp63α↑,
429- CUR,    TAp63α Is Involved in Tobacco Smoke-Induced Lung Cancer EMT and the Anti-cancer Activity of Curcumin via miR-19 Transcriptional Suppression
- in-vitro, Lung, H1299 - in-vitro, Lung, A549
TAp63α↑, E-cadherin↑, ZO-1↑, Vim↓, N-cadherin↓, miR-19b↓,
87- QC,    Quercetin inhibits prostate cancer by attenuating cell survival and inhibiting anti-apoptotic pathways
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
ROS⇅, BAX↑, PUMA⇅, β-catenin/ZEB1↓, Shc↓, TAp63α↑, MAPK↑, p‑p42↑, p‑p44↑, BIM↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS⇅, 1,  

Mitochondria & Bioenergetics ⓘ

p‑p42↑, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,  

Cell Death ⓘ

Akt↓, 1,   BAX↑, 1,   BIM↑, 1,   MAPK↑, 1,   PUMA⇅, 1,  

Transcription & Epigenetics ⓘ

Shc↓, 1,  

Cell Cycle & Senescence ⓘ

TAp63α↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

mTOR↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   miR-19b↓, 1,   N-cadherin↓, 1,   p‑p44↑, 1,   Vim↓, 1,   ZO-1↑, 1,   β-catenin/ZEB1↓, 1,  
Total Targets: 18

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TAp63α, TAp63α
2 Curcumin
1 Quercetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:432  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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