Database Query Results : , , HEY1

HEY1, Hairy/enhancer-of-split related with YRPW motif 1: Click to Expand ⟱
Source:
Type:
HEY1 (Hairy/enhancer-of-split related with YRPW motif 1) is a gene that plays a role in various biological processes, including development and cell differentiation.
HEY1 has been found to be overexpressed in various cancers, which can contribute to tumor growth and progression. It may influence pathways related to cell proliferation, apoptosis (programmed cell death), and angiogenesis (the formation of new blood vessels).
HEY1 is often found to be overexpressed in several cancers, including breast cancer, colorectal cancer, and glioblastoma. This overexpression can be associated with aggressive tumor behavior and poor prognosis.

Its overexpression is associated with various cancers, including breast, lung, colorectal, and hepatocellular carcinoma, often correlating with poor prognosis and aggressive tumor behavior.
Scientific Papers found: Click to Expand⟱
4660- Ash,    Withaferin A Alone and in Combination with Cisplatin Suppresses Growth and Metastasis of Ovarian Cancer by Targeting Putative Cancer Stem Cells
- in-vitro, Ovarian, NA
CSCs↓, TumCG↓, TumMeta↓, CD44↓, CD34↓, OCT4↓, NOTCH1↓, HEY1↓,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
27- EA,    Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice
- in-vivo, PC, NA
HH↓, Gli1↓, GLI2↓, cycD1/CCND1↓, CDK1/2/5/9↓, p‑Akt↓, NOTCH1↓, Akt↓, Shh↓, Snail↓, MMP2↓, MMP9↓, BAX↑, E-cadherin↑, NOTCH3↓, HEY1↓,
3469- MF,    Pulsed Electromagnetic Fields (PEMF)—Physiological Response and Its Potential in Trauma Treatment
- Review, NA, NA
*eff↑, *eff↝, *other↑, Ca+2↑, ROS↑, HSP70/HSPA5↑, *NOTCH↑, *HEY1↑, *p38↑, *MAPK↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ATF3↑, 1,   GSR↑, 1,   HO-1↑, 1,   lipid-P↑, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↑, 2,   SIRT3↑, 1,  

Mitochondria & Bioenergetics ⓘ

CDC2↓, 1,   mitResp↓, 1,   MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

LDHA↓, 1,   NADPH↑, 1,  

Cell Death ⓘ

Akt↓, 2,   p‑Akt↓, 1,   BAX↑, 1,   Bcl-2↓, 1,   cl‑Casp3↑, 1,   cl‑Casp9↑, 1,   Chk2↓, 1,   Cyt‑c↑, 1,   HEY1↓, 3,   MAPK↑, 1,   Mcl-1↓, 1,   p38↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

H3↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 1,  

DNA Damage & Repair ⓘ

CHK1↓, 1,   P53↑, 1,   PARP↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 1,   CDK4↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   P21↑, 1,   p‑RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CD34↓, 1,   CD44↓, 1,   CSCs↓, 2,   EMT↓, 1,   FOXO3↑, 1,   Gli1↓, 1,   HH↓, 1,   NOTCH↓, 1,   NOTCH1↓, 2,   NOTCH3↓, 1,   OCT4↓, 1,   Shh↓, 1,   STAT3↓, 1,   TumCG↓, 1,  

Migration ⓘ

AP-1↓, 1,   Ca+2↑, 1,   E-cadherin↑, 1,   ER-α36↓, 1,   GLI2↓, 1,   MMP2↓, 2,   MMP9↓, 2,   MMPs↓, 1,   N-cadherin↓, 1,   Slug↓, 1,   Snail↓, 2,   TumMeta↓, 1,   uPA↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

ATF4↑, 1,   PDGFR-BB↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 3,  

Clinical Biomarkers ⓘ

E6↓, 1,   E7↓, 1,  

Functional Outcomes ⓘ

RenoP↑, 1,  
Total Targets: 84

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Prx↑, 1,   SOD2↑, 1,  

Cell Death ⓘ

Casp3?, 1,   HEY1↑, 1,   MAPK↑, 1,   p38↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

NOTCH↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   eff↝, 1,  

Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 11

Scientific Paper Hit Count for: HEY1, Hairy/enhancer-of-split related with YRPW motif 1
2 Ashwagandha(Withaferin A)
1 Ellagic acid
1 Magnetic Fields
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:438  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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