Database Query Results : , , CYP11A1

CYP11A1, CYP11A1: Click to Expand ⟱
Source:
Type:
CYP11A1: gene that encodes a cytochrome P450 enzyme that catalyzes the conversion of cholesterol to pregnenolone, a precursor of steroid hormones.

Elevated CYP11A1 levels have been observed in cancer, and its expression may correlate with tumor aggressiveness and patient survival.
Scientific Papers found: Click to Expand⟱
131- CUR,    Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer
- vitro+vivo, Pca, LNCaP - vitro+vivo, Pca, 22Rv1
AKR1C2↓, CYP11A1↓, HSD3B↓, DHT↓, testos↓, StAR↓, SRD5A1↑,
1496- SFN,  VitD3,    Association between histone deacetylase activity and vitamin D-dependent gene expressions in relation to sulforaphane in human colorectal cancer cells
- in-vitro, CRC, Caco-2
eff↑, VDR↑, CYP11A1↓, HDAC↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,   VDR↑, 1,  

Migration ⓘ

AKR1C2↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CYP11A1↓, 2,   DHT↓, 1,   HSD3B↓, 1,   SRD5A1↑, 1,   StAR↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CYP11A1, CYP11A1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:454  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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