Database Query Results : , , IRP1

IRP1, Iron regulatory protein 1: Click to Expand ⟱
Source:
Type:
IRP1, a well-known iron regulatory protein, an important element in the regulation of iron homeostasis in animal cells.
Glioma patients with high expression of IRP1 had better survival prognosis.
Protumorigenic Effects
Iron Homeostasis: IRP1 regulates iron metabolism, and its upregulation can lead to increased iron availability, which supports tumor growth and proliferation.
Oxidative Stress: Elevated iron levels can contribute to oxidative stress, promoting DNA damage and tumor progression.
Cellular Proliferation: By enhancing iron uptake, IRP1 can support the metabolic demands of rapidly dividing cancer cells.

Generally, IRP1 has higher expression in cancers and is associated with worse prognosis, indicating its potential role in promoting tumors.
Scientific Papers found: Click to Expand⟱
135- CUR,    Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TfR1/CD71↑, IRP1↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

IRP1↑, 1,  

Metal & Cofactor Biology ⓘ

TfR1/CD71↑, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: IRP1, Iron regulatory protein 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:464  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page