Database Query Results : , , CDH1

CDH1, cadherin 1, type 1, E-cadherin (epithelial): Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
Cdh1 is the gene name, while E-cadherin is the protein product of that gene.
Cdh1 is the gene that encodes E-cadherin, which is a type of cadherin, a family of proteins involved in cell-cell adhesion. E-cadherin plays a crucial role in maintaining the structure and integrity of tissues by facilitating adhesion between epithelial cells. It is particularly important in the context of development and in the maintenance of epithelial tissue architecture.
Germline mutation in CDH1 (E-cadherin) tumor suppressor gene is associated with hereditary diffuse gastric cancer (HDGC) and lobular breast cancers (LBC).
In general, reduced or lost expression of E-cadherin (CDH1) is often associated with more aggressive tumor behavior, increased invasiveness, and poorer prognosis across various cancer types.
Scientific Papers found: Click to Expand⟱
3435- aLinA,    Alpha-linolenic acid-mediated epigenetic reprogramming of cervical cancer cell lines
- in-vitro, Cerv, HeLa - in-vitro, Cerv, SiHa - in-vitro, Cerv, C33A
DNMTs↓, HDAC↓, HATs↑, hTERT/TERT↓, CDH1↑, RARβ↑, DNMT1↓, DNMT3A↓, TET2↑, HDAC1↓, HDAC8↓, SIRT1↓, HMTs↑, EZH2↓,
756- Bor,    Evaluation of Boric Acid Treatment on microRNA‐127‐5p and Metastasis Genes Orchestration of Breast Cancer Stem Cells
- in-vitro, BC, MCF-7
COL1A1↓, Vim↓, miR-127-5p↑, Zeb1↑, CDH1↑, ITGB1↑, ITGA5↑, LAMA5↑, Snail↑,
736- Bor,    Evaluation of Boric Acid Treatment on microRNA-127-5p and Metastasis Genes Orchestration of Breast Cancer Stem Cells
- in-vitro, BC, MCF-7
miR-126↑, COL1A1↓, Vim↓, Zeb1↑, CDH1↑, ITGB1↑, ITGA5↑, LAMA5↑, Snail↑, miR-127-5p↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

RARβ↑, 1,   SIRT1↓, 1,  

Cell Death ⓘ

hTERT/TERT↓, 1,   miR-127-5p↑, 2,  

Transcription & Epigenetics ⓘ

EZH2↓, 1,   HATs↑, 1,  

DNA Damage & Repair ⓘ

DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,   HDAC1↓, 1,   HDAC8↓, 1,   HMTs↑, 1,  

Migration ⓘ

CDH1↑, 3,   COL1A1↓, 2,   ITGA5↑, 2,   ITGB1↑, 2,   LAMA5↑, 2,   Snail↑, 2,   Vim↓, 2,   Zeb1↑, 2,  

Angiogenesis & Vasculature ⓘ

miR-126↑, 1,  

Drug Metabolism & Resistance ⓘ

TET2↑, 1,  

Clinical Biomarkers ⓘ

EZH2↓, 1,   hTERT/TERT↓, 1,  
Total Targets: 25

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CDH1, cadherin 1, type 1, E-cadherin (epithelial)
2 Boron
1 alpha Linolenic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:50  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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