Database Query Results : , , CDK1/2/5/9

CDK1/2/5/9, Cyclin-dependent kinases (CDKs): Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Cyclin-dependent kinases (CDKs) are a family of protein kinases that play essential roles in regulating the cell cycle, transcription, and other cellular processes. CDK1, CDK2, CDK5, and CDK9 have been implicated in cancer through various mechanisms:
CDK1: regulation of the cell cycle. Overexpressed in various cancers.
CDK2: Functions mainly in the G1 to S phase transition of the cell cycle, working closely with cyclins D and E. Often overexpressed in cancers.
CDK5: primarily involved in neuronal function and is activated by p35 and p39. can promote or inhibit tumor growth depending on the context and the specific cancer type.
CDK9: regulating transcription by phosphorylating the C-terminal domain of RNA polymerase II. Often overrepresented in cancers.
Targeting these kinases with specific inhibitors is an area of active research in cancer therapy.
Scientific Papers found: Click to Expand⟱
314- Api,    Apigenin impairs oral squamous cell carcinoma growth in vitro inducing cell cycle arrest and apoptosis
- in-vitro, SCC, HaCaT - in-vitro, SCC, SCC25
TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK1/2/5/9∅,
27- EA,    Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice
- in-vivo, PC, NA
HH↓, Gli1↓, GLI2↓, cycD1/CCND1↓, CDK1/2/5/9↓, p‑Akt↓, NOTCH1↓, Akt↓, Shh↓, Snail↓, MMP2↓, MMP9↓, BAX↑, E-cadherin↑, NOTCH3↓, HEY1↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Akt↓, 1,   p‑Akt↓, 1,   BAX↑, 1,   HEY1↓, 1,  

Cell Cycle & Senescence ⓘ

CDK1/2/5/9↓, 1,   CDK1/2/5/9∅, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Gli1↓, 1,   HH↓, 1,   NOTCH1↓, 1,   NOTCH3↓, 1,   Shh↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   GLI2↓, 1,   MMP2↓, 1,   MMP9↓, 1,   Snail↓, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CDK1/2/5/9, Cyclin-dependent kinases (CDKs)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:51  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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