Database Query Results : , , angioS

angioS, angiostatin: Click to Expand ⟱
Source:
Type:
Angiostatin, a key protein that suppresses angiogenesis. Angiostatin may be used in anti-angiogenesis therapy. A protein that blocks angiogenesis (the growth of new blood vessels) and is involved in blood clotting.
Angiostatin is a protein that is known to inhibit angiogenesis, the process by which new blood vessels form from existing ones. It is derived from the cleavage of plasminogen and has been studied for its potential role in cancer biology, particularly in relation to tumor growth and metastasis.

Angiostatin in Cancer
Mechanism of Action: Angiostatin inhibits endothelial cell proliferation and migration, which are critical steps in angiogenesis. By preventing the formation of new blood vessels, angiostatin can limit the supply of nutrients and oxygen to tumors, potentially slowing their growth.

The expression levels of angiostatin in tumors have been associated with patient prognosis in some studies. Higher levels of angiostatin may correlate with better outcomes in certain cancers, as they may indicate a more effective anti-angiogenic response. Conversely, low levels of angiostatin might be associated with poor prognosis and more aggressive disease.
Scientific Papers found: Click to Expand⟱
155- CUR,    Osteopontin and MMP9: Associations with VEGF Expression/Secretion and Angiogenesis in PC3 Prostate Cancer Cells
- in-vitro, Pca, PC3
p‑ERK↓, VEGF↓, angioS↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,  

Angiogenesis & Vasculature ⓘ

angioS↑, 1,   VEGF↓, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: angioS, angiostatin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:514  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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