Database Query Results : , , NPY

NPY, Neuropeptide Y: Click to Expand ⟱

Source:

Type:

NPY and Y2R are overexpressed in human Colon cancer, orthotopic HT29, and most interestingly in VEGF-A-depleted orthotopic HT29 tumours.
NPY favors tumor cell growth, migration, and metastasis and promotes angiogenesis in some tumors (e.g., breast cancer, colorectal cancer, neuroblastoma, pancreatic cancer), whereas in others it exerts an antitumor effect (e.g., cholangiocarcinoma, Ewing sarcoma, liver cancer).
Increased NPY signaling has been correlated with aggressive features in certain tumors, as it may promote cell proliferation, angiogenesis, and migration.

– In cancers where NPY receptor expression is high, particularly the Y1 and Y2 receptors, the activation of NPY signaling cascades can correlate with poorer prognosis, tumor growth, or enhanced metastatic potential.

Scientific Papers found: Click to Expand⟱

191-

MFrot,

MF,

Early exposure of rotating magnetic fields promotes central nervous regeneration in planarian Girardia sinensis

in-vivo,

Nor,

  6 Hz 0.02 T RMFs.

 planarian Girardia sinensis worm

*EGR4↑, *Netrins↑, *NSE↑, *NPY↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Migration ⓘ

Netrins↑, 1,

Angiogenesis & Vasculature ⓘ

EGR4↑, 1, NPY↑, 1,

Clinical Biomarkers ⓘ

NSE↑, 1,
Total Targets: 4

Scientific Paper Hit Count for: NPY, Neuropeptide Y

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells