Database Query Results : , , MKP5

MKP5, MKP5: Click to Expand ⟱
Source:
Type:
MKPs have been shown to reverse the activation of the MAP kinases by hydrolyzing phosphothreonine and phosphotyrosine residues present in the substrates.
MKP5 (Mitogen-Activated Protein Kinase Phosphatase 5) is a dual-specificity phosphatase that plays a role in regulating MAPK signaling pathways, which are critical in various cellular processes, including proliferation, differentiation, and apoptosis.

MKP5 is generally downregulated in various cancers, and its low expression is often associated with poor prognosis and protumorigenic effects.


Scientific Papers found: Click to Expand⟱
182- CUR,  RES,  GI,    Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, LAPC-4
p38↓, MKP5↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

MKP5↑, 1,  

Cell Death ⓘ

p38↓, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MKP5, MKP5
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:529  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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