Database Query Results : , , IL17

IL17, Interleukin-17: Click to Expand ⟱
Source:
Type:
Also known as IL-17A.
Interleukin-17A is a protein that in humans is encoded by the IL17A gene.
Higher levels of serum IL-17 are associated with poor prognosis for a variety of solid tumors in cancer patients.
Scientific Papers found: Click to Expand⟱
2713- BBR,    Berberine improved the microbiota in lung tissue of colon cancer and reversed the bronchial epithelial cell changes caused by cancer cells
- in-vitro, Nor, BEAS-2B
*GutMicro↑, *IL6↑, *IL10↑, *IL17↑, *IFN-γ↑, PDGF↓, *RAD51↓,
2749- BetA,    Anti-Inflammatory Activities of Betulinic Acid: A Review
- Review, Nor, NA
Inflam↓, *NO↓, *IL10↑, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *NF-kB↓, *IKKα↓, *COX2↓, *PGE2↓, *IL1β↓, *IL6↓, *IL8↓, *IL12↓, *TNF-α↑, *HO-1↑, *IL10↑, *IL2↓, *IL17↓, *IFN-γ↓, *SOD↑, *GPx↑, *GSR↑, *MDA↓, *MAPK↓,
2794- CHr,    An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches
- Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *IL1β↓, *TNF-α↓, *COX2↓, *iNOS↓, *NF-kB↓, *JNK↓, *HDAC↓, *GSK‐3β↓, *IFN-γ↓, *IL17↓, *GSH↑, *NRF2↑, *HO-1↑, *SOD↑, *MDA↓, *NO↓, *GPx↑, *TBARS↓, *AChE↓, *GR↑, *Catalase↑, *VitC↑, *memory↑, *lipid-P↓, *ROS↓,
3795- CUR,    Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence
- Review, AD, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2↓, *MCP1↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE↓, *AChE↓, *LDL↓,
2246- MF,    The Use of Pulsed Electromagnetic Field to Modulate Inflammation and Improve Tissue Regeneration: A Review
- in-vitro, Nor, NA
*Inflam↓, *IL1↓, *IL6↓, IL17↓, *TNF-α↓,
193- MFrot,  MF,    Rotating Magnetic Field Mitigates Ankylosing Spondylitis Targeting Osteocytes and Chondrocytes via Ameliorating Immune Dysfunctions
- in-vivo, Arthritis, NA
BMD↑, Cartilage↑, IL17↓, IL22↓, IL23↓, IL28↓, CD4+↓, CD8+↓, LAMB3↑, COL4↓, THBS2↓, ITGA11↓, PPARγ↑, ACAA1↓, PLIN1↓, FABP4↓, PCK1↓, UCP1↓, TNF-α↓,
228- MFrot,  MF,    Rotating magnetic field ameliorates experimental autoimmune encephalomyelitis by promoting T cell peripheral accumulation and regulating the balance of Treg and Th1/Th17
- NA, MS, NA
*CD4+↑, *MCP1↓, RANTES↓, *MIP‑1α↓, *Treg lymp↓, *IFN-γ↓, *IL17↓, *CXCc↓,
2051- PB,    Beneficial Effects of Sodium Phenylbutyrate Administration during Infection with Salmonella enterica Serovar Typhimurium
- in-vivo, Inf, NA
*Inf↓, *GutMicro↑, *IL17↑, *Inflam↓, *ER Stress↓, *ROS↓, *OS↑, *Bacteria↓, *Neut↑, *toxicity↓,
1164- PI,    Inhibition of T cell activation by the phytochemical piperine
- in-vitro, Nor, NA
*other↓, *CD25+↓, *IFN-γ↓, *IL2↓, *IL4↓, *IL17↓, *CD69↓, *CTLA-4↓, *p‑ERK↓, *IKKα↓,
1938- PL,    Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation
- Study, PSA, NA - in-vivo, NA, NA
ROS↑, Apoptosis↑, MMP↓, TumCCA↑, DNAdam↑, STAT3↓, Akt↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, Bcl-2↓, K17↓, HDAC↓, ROS↑, *IL1β↓, *IL6↓, *TNF-α↓, *IL17↓, *IL22↓,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, eff↑, P-gp↓, eff↑, eff↑, eff↑, eff↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
2415- SK,    Shikonin induces programmed death of fibroblast synovial cells in rheumatoid arthritis by inhibiting energy pathways
- in-vivo, Arthritis, NA
Apoptosis?, TumAuto↑, ROS↑, ATP↓, Glycolysis↓, PI3K↓, Akt↓, mTOR↓, *Apoptosis↓, *Inflam↓, *TNF-α↓, *IL6↓, *IL8↓, *IL10↓, *IL17↓, *hepatoP↑, *RenoP↑, PKM2↓, GLUT1↓, HK2↓,
2201- SK,    Shikonin promotes ferroptosis in HaCaT cells through Nrf2 and alleviates imiquimod-induced psoriasis in mice
- in-vitro, PSA, HaCaT - in-vivo, NA, NA
*eff↑, *IL6↓, *IL17↓, *TNF-α↓, *lipid-P↑, *NRF2↓, *HO-1↝, *NCOA4↝, *GPx4↓, *Ferroptosis↓, *Inflam↓, *ROS↓, *Iron↓,
5021- UA,    Anticancer effect of ursolic acid via mitochondria-dependent pathways
- Review, Var, NA
Inflam↓, TNF-α↓, IL6↓, IL17↓, NF-kB↓, COX2↓, *AntiDiabetic↑, *hepatoP↑, ALAT↓, AST↓, TumCP↓, Apoptosis↑, TumCCA↑, TumAuto↑, tumCV↓, TumCMig↓, Glycolysis↓, ATP↓, lactateProd↓, HK2↓, PKA↓, COX2↓, mtDam↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, ROS↑, MMP↓, P53↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 14

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,   ROS↑, 4,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 2,   MMP↓, 3,   mtDam↑, 1,   UCP1↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACAA1↓, 1,   ALAT↓, 1,   cMyc↓, 1,   FABP4↓, 1,   Glycolysis↓, 2,   HK2↓, 2,   lactateProd↓, 1,   PCK1↓, 1,   PKM2↓, 1,   PLIN1↓, 1,   PPARγ↑, 1,  

Cell Death ⓘ

Akt↓, 3,   Apoptosis?, 1,   Apoptosis↑, 3,   BAX↓, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   MDM2↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

HSP70/HSPA5↓, 1,   HSP90↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 1,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   HDAC↓, 1,   mTOR↓, 1,   PI3K↓, 1,   RAS↓, 1,   STAT3↓, 1,   TOP2↓, 1,  

Migration ⓘ

Cartilage↑, 1,   COL4↓, 1,   ITGA11↓, 1,   Ki-67↓, 1,   KRAS↓, 1,   LAMB3↑, 1,   PDGF↓, 1,   PKA↓, 1,   PKCδ↓, 1,   THBS2↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↓, 1,   COX2↓, 2,   IL17↓, 3,   IL22↓, 1,   IL23↓, 1,   IL28↓, 1,   IL6↓, 1,   Inflam↓, 2,   NF-kB↓, 1,   RANTES↓, 1,   TNF-α↓, 2,  

Drug Metabolism & Resistance ⓘ

eff↑, 6,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,   BMD↑, 1,   IL6↓, 1,   Ki-67↓, 1,   KRAS↓, 1,  

Functional Outcomes ⓘ

K17↓, 1,  

Infection & Microbiome ⓘ

CD8+↓, 1,  
Total Targets: 83

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   Catalase↑, 2,   Ferroptosis↓, 1,   GPx↑, 2,   GPx4↓, 1,   GSH↑, 2,   GSR↑, 1,   HO-1↑, 4,   HO-1↝, 1,   Iron↓, 1,   lipid-P↓, 2,   lipid-P↑, 1,   MDA↓, 2,   MPO↓, 1,   NQO1↑, 1,   Nrf1↑, 1,   NRF2↓, 1,   NRF2↑, 3,   ROS↓, 6,   SOD↑, 4,   TBARS↓, 1,   VitC↑, 1,  

Metal & Cofactor Biology ⓘ

NCOA4↝, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   LDL↓, 1,   NADPH↓, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Apoptosis↓, 2,   Ferroptosis↓, 1,   iNOS↓, 1,   JNK↓, 1,   MAPK↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,  

DNA Damage & Repair ⓘ

RAD51↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,   GSK‐3β↓, 3,   HDAC↓, 1,   mTOR↓, 1,  

Migration ⓘ

CDK5↓, 1,   E-sel↓, 1,   Treg lymp↓, 1,   TXNIP↓, 1,   VCAM-1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   NO↓, 2,  

Immune & Inflammatory Signaling ⓘ

CD25+↓, 1,   CD4+↑, 1,   CD69↓, 1,   COX2↓, 4,   CTLA-4↓, 1,   CXCc↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 4,   IFN-γ↑, 1,   IKKα↓, 2,   IL1↓, 1,   IL10↓, 2,   IL10↑, 4,   IL12↓, 1,   IL17↓, 9,   IL17↑, 2,   IL1β↓, 5,   IL2↓, 2,   IL22↓, 1,   IL23↓, 1,   IL4↓, 1,   IL6↓, 5,   IL6↑, 1,   IL8↓, 2,   Inflam↓, 7,   MCP1↓, 3,   MIP‑1α↓, 1,   Neut↑, 1,   NF-kB↓, 3,   PGE2↓, 1,   TNF-α↓, 7,   TNF-α↑, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 2,   BDNF↑, 1,   tau↓, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 2,   BACE↓, 1,   NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

GR↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   eff↑, 1,   Half-Life↑, 1,  

Clinical Biomarkers ⓘ

BP↓, 1,   GutMicro↑, 2,   IL6↓, 5,   IL6↑, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 1,   hepatoP↑, 2,   memory↑, 2,   neuroP↑, 3,   OS↑, 2,   Pain↓, 1,   RenoP↑, 1,   toxicity↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,   Inf↓, 1,  
Total Targets: 105

Scientific Paper Hit Count for: IL17, Interleukin-17
3 Magnetic Fields
2 Magnetic Field Rotating
2 Shikonin
1 Berberine
1 Betulinic acid
1 Chrysin
1 Curcumin
1 Phenylbutyrate
1 Piperine
1 Piperlongumine
1 Quercetin
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:540  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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