Database Query Results : , , ITGA11

ITGA11, Integrin α11: Click to Expand ⟱
Source:
Type:
A crucial cell adhesion receptor involved in diverse biological processes.
ITGA11 expression is associated with poor prognoses. It significantly influences the tumor microenvironment by regulating collagen assembly and matrix remodeling, particularly through pathways such as TGF-β and Hedgehog signaling. Moreover, ITGA11 contributes to cancer progression via interconnected pathways like PI3K/AKT and PDGFBR/JNK, influencing tumor growth, invasion, and metastasis.
ITGA11 is also highly expressed in fibroblasts of head and neck, breast, pancreas, lung, colorectal and Gastric Cancer.
Scientific Papers found: Click to Expand⟱
193- MFrot,  MF,    Rotating Magnetic Field Mitigates Ankylosing Spondylitis Targeting Osteocytes and Chondrocytes via Ameliorating Immune Dysfunctions
- in-vivo, Arthritis, NA
BMD↑, Cartilage↑, IL17↓, IL22↓, IL23↓, IL28↓, CD4+↓, CD8+↓, LAMB3↑, COL4↓, THBS2↓, ITGA11↓, PPARγ↑, ACAA1↓, PLIN1↓, FABP4↓, PCK1↓, UCP1↓, TNF-α↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

UCP1↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACAA1↓, 1,   FABP4↓, 1,   PCK1↓, 1,   PLIN1↓, 1,   PPARγ↑, 1,  

Migration ⓘ

Cartilage↑, 1,   COL4↓, 1,   ITGA11↓, 1,   LAMB3↑, 1,   THBS2↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↓, 1,   IL17↓, 1,   IL22↓, 1,   IL23↓, 1,   IL28↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,  

Infection & Microbiome ⓘ

CD8+↓, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ITGA11, Integrin α11
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:548  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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