Database Query Results : , , FABP4

FABP4, Fatty acid-binding proteins 4: Click to Expand ⟱
Source:
Type:
Belongs to a family of intracellular lipid-binding protein, can bind hydrophobic ligands to regulate lipid trafficking and metabolism.
Has been found to be upregulated in many malignant solid tumors, and correlated with poor prognosis.
Scientific Papers found: Click to Expand⟱
3521- Bor,    A new hope for obesity management: Boron inhibits adipogenesis in progenitor cells through the Wnt/β-catenin pathway
- in-vitro, Obesity, 3T3
*CEBPA↓, *PPARγ↓, *FASN↓, *SREBP1↓, *FABP4↓, *GLUT4↓, *β-catenin/ZEB1↑, *MMP2↓, *FGF↑, *Ca+2?,
193- MFrot,  MF,    Rotating Magnetic Field Mitigates Ankylosing Spondylitis Targeting Osteocytes and Chondrocytes via Ameliorating Immune Dysfunctions
- in-vivo, Arthritis, NA
BMD↑, Cartilage↑, IL17↓, IL22↓, IL23↓, IL28↓, CD4+↓, CD8+↓, LAMB3↑, COL4↓, THBS2↓, ITGA11↓, PPARγ↑, ACAA1↓, PLIN1↓, FABP4↓, PCK1↓, UCP1↓, TNF-α↓,
218- MFrot,  MF,    Extremely low frequency magnetic fields inhibit adipogenesis of human mesenchymal stem cells
- in-vitro, Nor, NA
*PPARγ↓, *p‑JNK↑, *Wnt↑, *ALP∅, *COL1∅, *RUNX2∅, *OCN∅, *FABP4↓, *p‑JNK↑, *Diff↓,
3010- RosA,    Exploring the mechanism of rosmarinic acid in the treatment of lung adenocarcinoma based on bioinformatics methods and experimental validation
- in-vitro, Lung, A549 - in-vivo, NA, NA
TumCG↓, Ki-67↓, FABP4↑, PPARα↑, ROS↑, Apoptosis↑, MMP9↓, IGFBP3↓, MMP2↓, EMT↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, Gli1↓, PPARγ↑, Cyt‑c↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

UCP1↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACAA1↓, 1,   FABP4↓, 1,   FABP4↑, 1,   PCK1↓, 1,   PLIN1↓, 1,   PPARα↑, 1,   PPARγ↑, 2,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   Cyt‑c↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   Gli1↓, 1,   IGFBP3↓, 1,   mTOR↓, 1,   PI3K↓, 1,   TumCG↓, 1,  

Migration ⓘ

Cartilage↑, 1,   COL4↓, 1,   ITGA11↓, 1,   Ki-67↓, 1,   LAMB3↑, 1,   MMP2↓, 1,   MMP9↓, 1,   THBS2↓, 1,   TumCI↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↓, 1,   IL17↓, 1,   IL22↓, 1,   IL23↓, 1,   IL28↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,   Ki-67↓, 1,  

Infection & Microbiome ⓘ

CD8+↓, 1,  
Total Targets: 36

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis ⓘ

FABP4↓, 2,   FASN↓, 1,   PPARγ↓, 2,   SREBP1↓, 1,  

Cell Death ⓘ

p‑JNK↑, 2,  

Kinase & Signal Transduction ⓘ

OCN∅, 1,  

Proliferation, Differentiation & Cell State ⓘ

CEBPA↓, 1,   Diff↓, 1,   FGF↑, 1,   RUNX2∅, 1,   Wnt↑, 1,  

Migration ⓘ

Ca+2?, 1,   COL1∅, 1,   MMP2↓, 1,   β-catenin/ZEB1↑, 1,  

Barriers & Transport ⓘ

GLUT4↓, 1,  

Clinical Biomarkers ⓘ

ALP∅, 1,  
Total Targets: 17

Scientific Paper Hit Count for: FABP4, Fatty acid-binding proteins 4
2 Magnetic Field Rotating
2 Magnetic Fields
1 Boron
1 Rosmarinic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:551  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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