Database Query Results : , , UCP1

UCP1, mitochondrial uncoupling protein 1: Click to Expand ⟱
Source:
Type:
UCP1 for example has been shown to be expressed in prostate cancer and be related to a metastatic phenotype.
UCP1 and UCP3 are overexpressed in a large subgroup of non-small cell lung tumors and their expression coincides with increased glucose absorption, intensified glycolysis, and anaerobic glucose usage.
UCP1 was negatively regulated to the process of TNBC. Overexpression of UCP1 could impair the malignant behavior of triple-negative breast cancer. UCP1 was down-regulated in colorectal cancer while positively related to a better prognosis.
UCP1 is a mitochondrial inner membrane protein most notably expressed in brown adipose tissue, where it uncouples oxidative phosphorylation to produce heat rather than ATP.

– In cancer cachexia, increased UCP1 expression is linked to higher energy dissipation, contributing to weight loss and weakness, which can indirectly influence patient prognosis.
Scientific Papers found: Click to Expand⟱
2739- BetA,    Glycolytic Switch in Response to Betulinic Acid in Non-Cancer Cells
- in-vitro, Nor, HUVECs - in-vitro, Nor, MEF
*Glycolysis↑, *GlucoseCon↑, *Apoptosis↓, *UCP1↓, *AMPK↑, GLUT1↑, mt-ROS↑,
193- MFrot,  MF,    Rotating Magnetic Field Mitigates Ankylosing Spondylitis Targeting Osteocytes and Chondrocytes via Ameliorating Immune Dysfunctions
- in-vivo, Arthritis, NA
BMD↑, Cartilage↑, IL17↓, IL22↓, IL23↓, IL28↓, CD4+↓, CD8+↓, LAMB3↑, COL4↓, THBS2↓, ITGA11↓, PPARγ↑, ACAA1↓, PLIN1↓, FABP4↓, PCK1↓, UCP1↓, TNF-α↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

mt-ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

UCP1↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACAA1↓, 1,   FABP4↓, 1,   PCK1↓, 1,   PLIN1↓, 1,   PPARγ↑, 1,  

Migration ⓘ

Cartilage↑, 1,   COL4↓, 1,   ITGA11↓, 1,   LAMB3↑, 1,   THBS2↓, 1,  

Barriers & Transport ⓘ

GLUT1↑, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↓, 1,   IL17↓, 1,   IL22↓, 1,   IL23↓, 1,   IL28↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,  

Infection & Microbiome ⓘ

CD8+↓, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


Mitochondria & Bioenergetics ⓘ

UCP1↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   GlucoseCon↑, 1,   Glycolysis↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,  
Total Targets: 5

Scientific Paper Hit Count for: UCP1, mitochondrial uncoupling protein 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:553  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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