Database Query Results : , , NFAT

NFAT, nuclear factor of activated T cells: Click to Expand ⟱
Source:
Type:
NFAT is a family of transcription factors that play a crucial role in the regulation of gene expression in various cell types, including immune cells and cancer cells. NFAT proteins are involved in the regulation of cell growth, differentiation, and survival, and their dysregulation has been implicated in the development and progression of cancer.
NFAT family: NFAT1, NFAT2, NFAT3, NFAT4, and NFAT5.
Cell proliferation: NFAT proteins can regulate the expression of genes involved in cell cycle progression and cell growth, which can contribute to the development of cancer.
• Angiogenesis: NFAT proteins have been implicated in the regulation of angiogenesis, the process of new blood vessel formation, which is essential for tumor growth and metastasis.
• Metastasis: NFAT proteins can regulate the expression of genes involved in cell migration and invasion, which can contribute to the development of metastatic disease.
• Immune evasion: NFAT proteins can regulate the expression of genes involved in immune evasion, which can allow cancer cells to evade the immune system.

Studies have shown that NFAT proteins are overexpressed in several types of cancer, including breast, lung, and colon cancer.
Scientific Papers found: Click to Expand⟱
232- AL,    A Single Meal Containing Raw, Crushed Garlic Influences Expression of Immunity- and Cancer-Related Genes in Whole Blood of Humans
- Human, Nor, NA
*AhR↑, *ARNT↑, *Hif1a↑, *Jun↑, *NFAT↑, *NFAM1↑, *REL↑, *OSM↑, *NFAT↑, *CXCc↑, *IL2↑, *IL6↑, *LIF↑,
567- ART/DHA,    An Untargeted Proteomics and Systems-based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells
- in-vitro, Lung, BEAS-2B
NRF2↑, AP-1↑, NFAT↑,
874- B-Gluc,    Potential promising anticancer applications of β-glucans: a review
- Review, NA, NA
AntiCan↑, TumCG↓, BAX↑, Bcl-2↓, IFN-γ↑, PI3K/Akt↑, MAPK↑, NFAT↑, NF-kB↑, ROS↑, NK cell↑, TumCCA↑, ERK↓, Telomerase↓,
3761- H2,    Therapeutic Inhalation of Hydrogen Gas for Alzheimer's Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study
- Human, AD, NA
*cognitive↑, *BBB↑, *ROS↓, *NRF2↑, *Inflam↓, *NFAT↓, *FAO↓, *4-HNE↓, *PGC-1α↑, *Ferroptosis↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

NRF2↑, 1,   ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

PI3K/Akt↑, 1,  

Cell Death ⓘ

BAX↑, 1,   Bcl-2↓, 1,   MAPK↑, 1,   Telomerase↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   TumCG↓, 1,  

Migration ⓘ

AP-1↑, 1,   NFAT↑, 2,  

Immune & Inflammatory Signaling ⓘ

IFN-γ↑, 1,   NF-kB↑, 1,   NK cell↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

4-HNE↓, 1,   Ferroptosis↓, 1,   NRF2↑, 1,   ROS↓, 1,  

Mitochondria & Bioenergetics ⓘ

PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

FAO↓, 1,  

Cell Death ⓘ

AhR↑, 1,   Ferroptosis↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

Jun↑, 1,  

Migration ⓘ

NFAM1↑, 1,   NFAT↓, 1,   NFAT↑, 2,  

Angiogenesis & Vasculature ⓘ

Hif1a↑, 1,   REL↑, 1,  

Barriers & Transport ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

CXCc↑, 1,   IL2↑, 1,   IL6↑, 1,   Inflam↓, 1,   LIF↑, 1,   OSM↑, 1,  

Hormonal & Nuclear Receptors ⓘ

ARNT↑, 1,  

Clinical Biomarkers ⓘ

IL6↑, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,  
Total Targets: 24

Scientific Paper Hit Count for: NFAT, nuclear factor of activated T cells
1 Allicin (mainly Garlic)
1 Artemisinin
1 beta-glucans
1 Hydrogen Gas
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:586  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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