Database Query Results : , , FasL

FasL, Fas ligand: Click to Expand ⟱
Source:
Type:
Fas ligand (FasL) is a protein that plays a crucial role in the regulation of the immune system and programmed cell death, also known as apoptosis. In the context of cancer, FasL has been found to have both tumor-promoting and tumor-suppressing effects.
FasL is upregulated in melanoma, colon.
FasL: tumor suppressing effect on Breast and Lung cancer.

FasL inhibitors, which block the interaction between Fas and FasL, have been shown to enhance the effectiveness of chemotherapy and immunotherapy
Scientific Papers found: Click to Expand⟱
1521- Ba,    Baicalein induces apoptosis via ROS-dependent activation of caspases in human bladder cancer 5637 cells
- in-vitro, Bladder, 5637
TumCG↓, Apoptosis↑, IAP1↓, IAP2↓, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, MMP↓, Casp8↑, BID↑, ROS?, eff↓, DR4↑, DR5↑, FasL↑, TRAIL↑,
1524- Ba,    Baicalein Induces Caspase‐dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells
- in-vitro, Lung, A549
DR5↑, FADD↑, FasL↑, Casp8↑, cFLIP↓, Casp3↑, Casp9↑, cl‑PARP↑, MMP↓, BID↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑, Apoptosis↑, TumCCA↑, DR5↑, FasL↑, DR4∅, cFLIP↓, FADD↑, MMPs↓,
2476- Ba,    Baicalein Induces Caspase-dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells
- in-vitro, Lung, A549
TumCG↓, Apoptosis↑, DR5↑, FasL↑, FADD↑, Casp8↑, cFLIP↓, Casp9↑, Casp3↑, cl‑PARP↑, MMP↓, BID↑, BAX↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1↓, PGE2↓, COX2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2691- BBR,    Berberine induces FasL-related apoptosis through p38 activation in KB human oral cancer cells
- in-vitro, Oral, KB
tumCV↓, DNAdam↑, Casp3↑, Casp7↑, FasL↑, Casp8↑, Casp9↑, PARP↑, BAX↑, BAD↑, APAF1↑, MMP2↓, MMP9↓, p‑p38↑, ERK↑, MAPK↑,
4493- Chit,  Selenate,  Se,    A novel synthetic chitosan selenate (CS) induces apoptosis in A549 lung cancer cells via the Fas/FasL pathway
- in-vitro, Lung, A549
tumCV↓, Apoptosis↑, TumCCA↑, Fas↑, FasL↑, FADD↑, Casp↑,
1145- CHr,    Chrysin inhibits propagation of HeLa cells by attenuating cell survival and inducing apoptotic pathways
- in-vitro, Cerv, HeLa
tumCV↓, BAX↑, BID↑, BOK↑, APAF1↑, TNF-α↑, FasL↑, Fas↑, FADD↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Mcl-1↓, NAIP↓, Bcl-2↓, CDK4↓, CycB/CCNB1↓, cycD1/CCND1↓, cycE1↓, TRAIL↑, p‑Akt↓, Akt↓, mTOR↓, PDK1↓, BAD↓, GSK‐3β↑, AMPK↑, p27↑, P53↑,
4455- DFE,    Ajwa Date (Phoenix dactylifera L.) Extract Inhibits Human Breast Adenocarcinoma (MCF7) Cells In Vitro by Inducing Apoptosis and Cell Cycle Arrest
- in-vitro, BC, MCF-7 - in-vitro, Nor, 3T3
TumCCA↑, P53↑, BAX↑, Casp3↑, MMP↓, Fas↑, FasL↑, Bcl-2↓, Apoptosis↑, TumCP↓, TUNEL↑, eff↑, selectivity↑,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
2005- Plum,    Plumbagin induces apoptosis in lymphoma cells via oxidative stress mediated glutathionylation and inhibition of mitogen-activated protein kinase phosphatases (MKP1/2)
- in-vivo, Nor, EL4 - in-vitro, AML, Jurkat
JNK↑, Cyt‑c↑, FasL↑, BAX↑, ROS↑, *ROS↑, MKP1↓, MKP2↓, selectivity∅, tumCV↑, Cyt‑c↑, Casp3↑, GSH/GSSG↓, ROS↑, mt-ROS↑, *ROS↑, eff↓,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1↑, IL1β↓, CRP↓, IL10↓, COX2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
1489- RES,    Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer
- Review, Var, NA
RadioS↑, ChemoSen↑, *BioAv↓, *BioAv↑, Ferroptosis↑, lipid-P↑, xCT↓, GPx4↓, *BioAv↑, COX2↓, cycD1/CCND1↓, FasL↓, FOXP3↓, HLA↑, p‑NF-kB↓, BAX↑, Bcl-2↓, MALAT1↓,
4486- Se,  Chit,    Selenium-Modified Chitosan Induces HepG2 Cell Apoptosis and Differential Protein Analysis
- in-vitro, Liver, HepG2
Apoptosis↑, TumCCA↑, MMP↓, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Risk↓, *BioAv↑, *toxicity↑, TumCG↓, AntiTum↑, ROS↑, Cyt‑c↑, Fas↑, FasL↑, FADD↑,
3289- SIL,    Silymarin: a promising modulator of apoptosis and survival signaling in cancer
- Review, Var, NA
*BioAv↝, *BioAv↓, Fas↑, FasL↑, FADD↑, pro‑Casp8↑, Apoptosis↑, DR5↑, Bcl-2↑, BAX↑, Casp3↑, PI3K↓, FOXM1↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, Akt↑, angioG↓, STAT3↓, NF-kB↓, lipid-P↓, eff↑, CDK1↓, survivin↓, CycB/CCNB1↓, Mcl-1↓, Casp9↑, AP-1↓, BioAv↑,
1824- VitK2,    Vitamin K and its analogs: Potential avenues for prostate cancer management
- Review, Pca, NA
AntiCan↑, toxicity∅, Risk↓, Apoptosis↑, ROS↑, TumCCA↑, eff↑, DNAdam↑, MMP↓, Cyt‑c↑, pro‑Casp3↑, FasL↑, Fas↑, TumAuto↑, ChemoSen↑, RadioS↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 15

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   CYP1A1↓, 1,   Ferroptosis↑, 1,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 2,   GSH↑, 1,   GSH/GSSG↓, 1,   GSR↓, 1,   GSTs↓, 1,   HO-1↓, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↓, 1,   NQO1↓, 1,   NRF2↓, 1,   NRF2↑, 1,   ROS?, 1,   ROS↓, 1,   ROS↑, 9,   mt-ROS↑, 1,   SOD↓, 1,   SOD↑, 1,   SOD2↓, 1,   VitC↓, 1,   VitE↓, 1,   xCT↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   BOK↑, 1,   CDC25↓, 2,   EGF↓, 1,   FGFR1↓, 1,   MMP↓, 7,   Raf↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 4,   cMyc↓, 1,   LDH↑, 1,   PDK1↓, 1,   SIRT1↓, 1,  

Cell Death ⓘ

Akt↓, 2,   Akt↑, 1,   p‑Akt↓, 2,   APAF1↑, 2,   Apoptosis↑, 9,   BAD↓, 1,   BAD↑, 1,   Bak↑, 1,   BAX↑, 11,   Bcl-2↓, 8,   Bcl-2↑, 1,   Bcl-xL↓, 1,   BID↑, 4,   Casp↑, 1,   Casp1↓, 1,   Casp3↓, 2,   Casp3↑, 9,   cl‑Casp3↑, 1,   pro‑Casp3↑, 1,   Casp7↑, 2,   Casp8↑, 7,   pro‑Casp8↑, 1,   Casp9↑, 8,   cl‑Casp9↑, 1,   cFLIP↓, 3,   Cyt‑c↑, 9,   DR4↑, 1,   DR4∅, 1,   DR5↑, 7,   FADD↑, 7,   Fas↑, 8,   FasL↓, 1,   FasL↑, 15,   Ferroptosis↑, 1,   HGF/c-Met↓, 1,   IAP1↓, 2,   IAP2↓, 1,   JNK↑, 1,   p‑JNK↑, 1,   MAPK↓, 3,   MAPK↑, 2,   Mcl-1↓, 2,   MDM2↓, 1,   p‑MDM2↓, 1,   MKP1↓, 1,   MKP2↓, 1,   NAIP↓, 1,   p27↑, 1,   p38↑, 1,   p‑p38↑, 2,   survivin↓, 2,   TRAIL↑, 2,   TUNEL↑, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics ⓘ

H3↓, 1,   H4↓, 1,   miR-21↑, 1,   other↓, 1,   p‑pRB↓, 1,   tumCV↓, 3,   tumCV↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 2,   p‑eIF2α↑, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3B-II↑, 1,   LC3II↑, 2,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

ATM↑, 1,   DNAdam↑, 2,   P53↑, 4,   PARP↓, 1,   PARP↑, 2,   cl‑PARP↑, 2,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 2,   CDK2↑, 1,   CDK4↓, 1,   CycB/CCNB1↓, 4,   cycD1/CCND1↓, 2,   cycE1↓, 1,   RB1↑, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State ⓘ

CD34↓, 1,   cFos↑, 1,   CSCs↓, 1,   EMT↓, 2,   EMT↑, 1,   ERK↓, 1,   ERK↑, 2,   FGF↓, 1,   FOXM1↓, 1,   GSK‐3β↑, 1,   HDAC↓, 1,   IGFBP3↑, 1,   mTOR↓, 4,   p‑mTOR↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 2,   p‑PI3K↓, 1,   PTEN↓, 1,   RAS↓, 2,   Shh↓, 1,   p‑Src↓, 1,   STAT3↓, 2,   p‑STAT6↓, 1,   TumCG↓, 3,   Wnt↓, 1,  

Migration ⓘ

AP-1↓, 1,   AXL↓, 1,   Cdc42↓, 1,   CEA↓, 1,   CLDN1↓, 1,   E-cadherin↓, 1,   FAK↓, 3,   HLA↑, 1,   ITGB1↓, 1,   MALAT1↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 4,   MMP3↓, 1,   MMP9↓, 3,   MMPs↓, 2,   N-cadherin↓, 1,   PDGF↓, 1,   Rac1↓, 1,   Rho↓, 2,   ROCK1↓, 1,   Snail↓, 1,   TGF-β↓, 2,   TSP-1↑, 1,   TumCI↓, 1,   TumCP↓, 2,   TumMeta↓, 1,   Tyro3↓, 1,   uPA↓, 2,   uPAR↓, 1,   Vim↑, 1,   ZO-1↑, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 3,   EGFR↓, 1,   EGFR↑, 1,   Hif1a↓, 1,   VEGF↓, 2,   VEGFR2↓, 1,  

Immune & Inflammatory Signaling ⓘ

ASC↓, 1,   CD4+↓, 1,   COX2↓, 4,   CRP↓, 1,   FOXP3↓, 1,   ICAM-1↓, 1,   IKKα↓, 1,   IL1↓, 1,   IL10↓, 1,   IL1β↓, 1,   IL2↑, 1,   IL6↓, 3,   Inflam↓, 1,   MCP1↓, 1,   NF-kB↓, 5,   p‑NF-kB↓, 1,   p‑p65↓, 1,   PD-1↓, 1,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 2,   TNF-α↑, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 2,   ChemoSen↑, 4,   eff↓, 4,   eff↑, 5,   RadioS↑, 3,   selectivity↑, 1,   selectivity∅, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   CEA↓, 1,   CRP↓, 1,   EGFR↓, 1,   EGFR↑, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   IL6↓, 3,   LDH↑, 1,   NSE↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiTum↑, 2,   cachexia↓, 1,   chemoP↑, 1,   RenoP↑, 1,   Risk↓, 2,   toxicity∅, 1,  
Total Targets: 241

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 2,   GPx↑, 2,   GSH↑, 1,   GSTs↑, 1,   lipid-P↓, 1,   ROS↓, 1,   ROS↑, 2,   SOD↑, 1,  

Cell Death ⓘ

Casp3↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL10↑, 1,   IL1β↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 3,   BioAv↝, 1,   eff↑, 1,   Half-Life↝, 1,  

Functional Outcomes ⓘ

toxicity↑, 1,  
Total Targets: 19

Scientific Paper Hit Count for: FasL, Fas ligand
3 Baicalein
2 Berberine
2 chitosan
2 Selenium
1 Selenate
1 Chrysin
1 Date Fruit Extract
1 Luteolin
1 Plumbagin
1 Quercetin
1 Resveratrol
1 Silymarin (Milk Thistle) silibinin
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:593  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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