Database Query Results : , , Akt2
Akt2, RAC-beta serine/threonine-protein kinase: Click to Expand ⟱
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Enzyme that in humans is encoded by the AKT2 gene.
AKT2 is highly expressed in many human cancers, including non-small cell lung cancer (NSCLC). miR-124 overexpression can negatively regulate AKT2. knockout of both AKT1 and AKT2 will attenuate metastasis and tumor cell growth.
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Scientific Papers found: Click to Expand⟱
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in-vitro, |
BC, |
MDA-MB-231 |
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other↑, *antiOx↑, Risk↓, other↑, TumMeta↓, ECM/TCF↓, Akt2↓, Ferroptosis↑, eff↑,
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1↓, Hif1a↓, LC3II↑, Beclin-1↑,
TumCP↓, TumCCA↑, Apoptosis↑, *neuroP↑, *NF-kB↓, *JNK↓, *NRF2↑, *BDNF↑, *Ca+2↝, *antiOx↑, *AntiCan↑, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *TNF-α↓, NF-kB↓, DNAdam↓, PSA↓, P53↓, cycD1/CCND1↓, NRF2↓, Akt2↓, PPARγ↓,
PI3K↓, Akt↓, NF-kB↓, Wnt/(β-catenin)↓, MAPK↓, TumCP↓, TumCCA↑, Apoptosis↑, p‑EGFR↓, JAK2↓, STAT5↓, cycD1/CCND1↓, hTERT/TERT↓, AP-1↓, MMP9↓, miR-21↓, miR-155↓, Casp9↑, BID↑, ERK↓, Akt2↓, DNMT1↓, P53↑, survivin↓, Casp3↑, ROS↑,
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
Ferroptosis↑, 1, NRF2↓, 1, ROS↑, 2, SOD↓, 1,
Metal & Cofactor Biology ⓘ
IronCh↑, 1,
Mitochondria & Bioenergetics ⓘ
BOK↑, 1, MMP↓, 1, mtDam↑, 1, XIAP↓, 1,
Core Metabolism/Glycolysis ⓘ
AKT1↓, 1, cMyc↓, 1, PPARγ↓, 1,
Cell Death ⓘ
Akt↓, 1, Akt↑, 1, Apoptosis↑, 2, BAD↑, 1, BAX↑, 1, Bcl-2↓, 1, BID↑, 2, cl‑Casp12↑, 1, Casp3↑, 2, Casp9↑, 2, Cyt‑c↑, 1, DR5↑, 1, FADD↑, 1, Fas↑, 1, Ferroptosis↑, 1, hTERT/TERT↓, 2, MAPK↓, 2, Mcl-1↓, 1, NAIP↓, 1, survivin↓, 1, Telomerase↓, 1,
Transcription & Epigenetics ⓘ
miR-21↓, 1, other↑, 2,
Protein Folding & ER Stress ⓘ
eIF2α↑, 1, ER Stress↑, 1, PERK↑, 1,
Autophagy & Lysosomes ⓘ
Beclin-1↑, 1, LC3II↑, 1,
DNA Damage & Repair ⓘ
DNAdam↓, 1, DNMT1↓, 1, P53↓, 1, P53↑, 1,
Cell Cycle & Senescence ⓘ
CDK2↓, 1, CDK4↓, 1, cycD1/CCND1↓, 2, TumCCA↑, 3,
Proliferation, Differentiation & Cell State ⓘ
EMT↓, 1, ERK↓, 1, PI3K↓, 2, STAT5↓, 1, Wnt/(β-catenin)↓, 1,
Migration ⓘ
Akt2↓, 4, AP-1↓, 1, Ca+2↑, 1, E-cadherin↑, 1, miR-155↓, 1, MMP9↓, 1, N-cadherin↓, 1, TumCP↓, 3, TumMeta↓, 1, Vim↓, 1,
Angiogenesis & Vasculature ⓘ
angioG↓, 1, ATF4↑, 1, ECM/TCF↓, 1, p‑EGFR↓, 1, Hif1a↓, 1,
Immune & Inflammatory Signaling ⓘ
JAK2↓, 1, NF-kB↓, 3, PSA↓, 1,
Drug Metabolism & Resistance ⓘ
eff↑, 1,
Clinical Biomarkers ⓘ
p‑EGFR↓, 1, hTERT/TERT↓, 2, PSA↓, 1,
Functional Outcomes ⓘ
Risk↓, 1,
Total Targets: 76
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
antiOx↑, 2, GSH↑, 1, NRF2↑, 1, ROS↓, 1, SOD↑, 1,
Core Metabolism/Glycolysis ⓘ
LDHA↑, 1,
Cell Death ⓘ
JNK↓, 1,
Autophagy & Lysosomes ⓘ
Beclin-1↓, 1,
Migration ⓘ
Ca+2↝, 1,
Immune & Inflammatory Signaling ⓘ
IL1↓, 1, IL6↓, 1, IL8↓, 1, Inflam↓, 1, NF-kB↓, 1, TNF-α↓, 1,
Synaptic & Neurotransmission ⓘ
BDNF↑, 1,
Drug Metabolism & Resistance ⓘ
BioAv↓, 1,
Clinical Biomarkers ⓘ
IL6↓, 1,
Functional Outcomes ⓘ
AntiCan↑, 1, neuroP↑, 2,
Total Targets: 20
Scientific Paper Hit Count for: Akt2, RAC-beta serine/threonine-protein kinase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:6 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid
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