Database Query Results : , , GRP58

GRP58, GRP58/ERp57: Click to Expand ⟱
Source:
Type:
Also known as ERp57
A molecular chaperone that plays a crucial role in the endoplasmic reticulum (ER) stress response.
ERp57 is often overexpressed, which can contribute to tumor growth and survival.
ERp57 can promote cancer cell proliferation, migration, and invasion by regulating various signaling pathways, including the PI3K/AKT and MAPK/ERK pathways. Additionally, ERp57 can also inhibit apoptosis (programmed cell death) in cancer cells, which can contribute to tumor progression.
Scientific Papers found: Click to Expand⟱
264- ALA,    α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells
- in-vitro, HCC, FaO
ROS↑, P53↑, ER Stress↑, UPR↑, CHOP↑, PDI↑, GRP78/BiP↑, GRP58↓,
3337- QC,    Endoplasmic Reticulum Stress-Relieving Effect of Quercetin in Thapsigargin-Treated Hepatocytes
- in-vitro, NA, HepG2
*Inflam↓, *UPR↓, *GRP58↓, *XBP-1↓, *ER Stress↓, *antiOx↑, TNF-α↓, p‑eIF2α↓, p‑IRE1↓, p‑JNK↓, CHOP↓,
2355- SK,    Pharmacological properties and derivatives of shikonin-A review in recent years
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, Apoptosis↑, TumAuto↑, Necroptosis↑, ROS↑, TrxR1↓, PKM2↓, RIP1↓, RIP3↓, Src↓, FAK↓, PI3K↓, Akt↓, mTOR↓, GRP58↓, MMPs↓, ATF2↓, cl‑PARP↑, Casp3↑, p‑p38↑, p‑JNK↑, p‑ERK↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 2,   TrxR1↓, 1,  

Core Metabolism/Glycolysis ⓘ

PKM2↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   ATF2↓, 1,   Casp3↑, 1,   GRP58↓, 2,   p‑JNK↓, 1,   p‑JNK↑, 1,   Necroptosis↑, 1,   p‑p38↑, 1,   RIP1↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   CHOP↑, 1,   p‑eIF2α↓, 1,   ER Stress↑, 1,   GRP78/BiP↑, 1,   p‑IRE1↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,   cl‑PARP↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,   mTOR↓, 1,   PI3K↓, 1,   Src↓, 1,  

Migration ⓘ

FAK↓, 1,   MMPs↓, 1,   RIP3↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

PDI↑, 1,  

Immune & Inflammatory Signaling ⓘ

TNF-α↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 35

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,  

Cell Death ⓘ

GRP58↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,   UPR↓, 1,   XBP-1↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  
Total Targets: 6

Scientific Paper Hit Count for: GRP58, GRP58/ERp57
1 Alpha-Lipoic-Acid
1 Quercetin
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:600  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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