Database Query Results : , , lysosome

lysosome, lysosome/lysosomal: Click to Expand ⟱
Source:
Type:
Lysosomes are membrane-bound organelles that play a crucial role in cellular homeostasis by degrading and recycling various biomolecules, including proteins, lipids, and carbohydrates. They contain a variety of hydrolytic enzymes that facilitate these processes. In the context of cancer, lysosomes are increasingly recognized for their roles in tumor biology, influencing cell survival, proliferation, and metastasis.

Lysosomes are generally considered protumorigenic in many contexts. Their role in degrading extracellular matrix components and releasing proteolytic enzymes can facilitate tumor cell invasion and metastasis. Additionally, lysosomes can support cancer cell survival by providing nutrients through autophagy and recycling processes.
Scientific Papers found: Click to Expand⟱
318- AgNPs,    Silver nanoparticles regulate autophagy through lysosome injury and cell hypoxia in prostate cancer cells
- in-vitro, Pca, PC3
lysoM↓, lysosome↓, AMPKα↑, TumAuto↑, mTOR↑,
5173- Ash,  2DG,    Withaferin A inhibits lysosomal activity to block autophagic flux and induces apoptosis via energetic impairment in breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468 - in-vitro, BC, T47D
autoF↓, lysosome↓, TumAuto↑, p‑LDH↓, ATP↓, AMPK↑, eff↑, TumCG↓, CTSD↓, CTSB↓, CTSL↑, cl‑PARP1↑, LDHA↓, TCA↓,
1297- CA,    Caffeic Acid Phenethyl Ester (CAPE) Induced Apoptosis in Serous Ovarian Cancer OV7 Cells by Deregulation of BCL2/BAX Genes
- in-vitro, Ovarian, OV7
lysosome↓, Apoptosis↑, Bax:Bcl2↑,
5125- Sal,    Salinomycin induced ROS results in abortive autophagy and leads to regulated necrosis in glioblastoma
- in-vitro, GBM, NA
ER Stress↑, UPR↑, autoF↓, lysosome↝, ROS↑, lipid-P↑, CSCs↓, necrosis↑, ATP↓, MMP↓, MOMP↑, DNAdam↑, AIF↑, lysoMP↑, MitoP↑, Ca+2↑,
5124- Sal,    Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance
- in-vitro, BC, NA
CSCs↓, LC3II↑, other↓, lysosome↓, CTSZ↓, CTSB↓, CTSL↓, CTSS↓, autoF↓, TumAuto↓,
4868- Uro,    Urolithin A improves Alzheimer’s disease cognition and restores mitophagy and lysosomal functions
- in-vivo, AD, NA
*memory↑, *Aβ↓, *tau↓, *MitoP↑, *lysosome↑, *CTSZ↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

lipid-P↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 2,   MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   p‑LDH↓, 1,   LDHA↓, 1,   TCA↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Bax:Bcl2↑, 1,   lysoMP↑, 1,   MOMP↑, 1,   necrosis↑, 1,  

Kinase & Signal Transduction ⓘ

AMPKα↑, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

autoF↓, 3,   LC3II↑, 1,   lysoM↓, 1,   lysosome↓, 4,   lysosome↝, 1,   MitoP↑, 1,   TumAuto↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   cl‑PARP1↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 2,   CTSB↓, 2,   CTSD↓, 1,   CTSL↓, 1,   CTSL↑, 1,   CTSS↓, 1,   mTOR↑, 1,   TumCG↓, 1,  

Migration ⓘ

Ca+2↑, 1,  

Immune & Inflammatory Signaling ⓘ

CTSZ↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Clinical Biomarkers ⓘ

p‑LDH↓, 1,  
Total Targets: 40

Pathway results for Effect on Normal Cells:


Autophagy & Lysosomes ⓘ

lysosome↑, 1,   MitoP↑, 1,  

Immune & Inflammatory Signaling ⓘ

CTSZ↝, 1,  

Synaptic & Neurotransmission ⓘ

tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Functional Outcomes ⓘ

memory↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: lysosome, lysosome/lysosomal
2 salinomycin
1 Silver-NanoParticles
1 Ashwagandha(Withaferin A)
1 2-DeoxyGlucose
1 Caffeic acid
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:616  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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