Database Query Results : , , TOS

TOS, total oxidant status: Click to Expand ⟱
Source:
Type:
Total oxidant status (TOS) refers to the overall level of oxidants in the body, which can be an important factor in cancer biology. Oxidative stress, resulting from an imbalance between oxidants and antioxidants, is implicated in cancer development, progression, and metastasis.
Elevated TOS can lead to DNA damage, promote inflammation, and affect cell signaling pathways, all of which can contribute to tumorigenesis.
Elevated TOS levels have been associated with poor prognosis in various cancers.
Oxidative Stress Markers:
Reactive Oxygen Species (ROS): Includes superoxide anions, hydrogen peroxide, and hydroxyl radicals. Malondialdehyde (MDA): A byproduct of lipid peroxidation, often used as a marker for oxidative stress.
8-Hydroxydeoxyguanosine (8-OHdG): A marker of oxidative DNA damage.
Protein Carbonyls: Indicators of protein oxidation.
2. Antioxidant Defense Mechanisms:
Superoxide Dismutase (SOD): Enzyme that catalyzes the dismutation of superoxide into oxygen and hydrogen peroxide.
Catalase: Enzyme that converts hydrogen peroxide into water and oxygen.
Glutathione Peroxidase (GPx): Reduces hydrogen peroxide and lipid peroxides.
Glutathione (GSH): A major antioxidant that protects cells from oxidative stress.
Scientific Papers found: Click to Expand⟱
3516- Bor,    Boron in wound healing: a comprehensive investigation of its diverse mechanisms
- Review, Wounds, NA
*Inflam↓, *antiOx↑, *ROS↓, *angioG↑, *COL1↑, *α-SMA↑, *TGF-β↑, *BMD↑, *hepatoP↑, *TNF-α↑, *HSP70/HSPA5↑, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *TOS↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *lipid-P↓, *VEGF↑, *Half-Life↝,
718- Bor,    Boric Acid Exhibits Anticancer Properties in Human Endometrial Cancer Ishikawa Cells
- in-vitro, NA, NA
OSI↑, TNF-α↓, IL1↓, Casp3↑, Apoptosis↑, TOS↑,
719- Bor,    Boric Acid Affects Cell Proliferation, Apoptosis, and Oxidative Stress in ALL Cells
- in-vitro, Var, NA
Apoptosis↑, miR-21↓, TOS↓,
729- Bor,    Promising potential of boron compounds against Glioblastoma: In Vitro antioxidant, anti-inflammatory and anticancer studies
- in-vitro, GBM, U87MG - in-vivo, Nor, HaCaT
TOS↑, TumCG↓, MDA↑, SOD↑, Catalase↑, TAC↓, GSH↓, BRAF↑, MAPK↓, PTEN↓, Raf↓, *toxicity↓,
760- Bor,    Therapeutic Efficacy of Boric Acid Treatment on Brain Tissue and Cognitive Functions in Rats with Experimental Alzheimer’s Disease
- in-vivo, AD, NA
*memory↑, *ROS↓, *GSH↑, *Aβ↓, *Inflam↓, *MMP↑, *lipid-P↓, *Ca+2↓, *cognitive↑, *TOS↓,
377- SNP,    Anticancer Action of Silver Nanoparticles in SKBR3 Breast Cancer Cells through Promotion of Oxidative Stress and Apoptosis
- in-vitro, BC, SkBr3
ROS↑, Apoptosis↑, Bax:Bcl2↑, VEGF↑, Akt↓, PI3K↓, TAC↓, TOS↑, OSI↑, MDA↑, Casp3↑, Casp7↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GSH↓, 1,   MDA↑, 2,   OSI↑, 2,   ROS↑, 1,   SOD↑, 1,   TAC↓, 2,   TOS↓, 1,   TOS↑, 3,  

Mitochondria & Bioenergetics ⓘ

Raf↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 3,   Bax:Bcl2↑, 1,   Casp3↑, 2,   Casp7↑, 1,   MAPK↓, 1,  

Transcription & Epigenetics ⓘ

miR-21↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

BRAF↑, 1,   PI3K↓, 1,   PTEN↓, 1,   TumCG↓, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL1↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

BRAF↑, 1,  
Total Targets: 25

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 1,   GSH↑, 2,   lipid-P↓, 2,   MDA↓, 1,   ROS↓, 2,   SOD↑, 1,   TOS↓, 2,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,  

Protein Folding & ER Stress ⓘ

HSP70/HSPA5↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

STAT3↓, 1,  

Migration ⓘ

Ca+2↓, 1,   COL1↑, 1,   TGF-β↑, 1,   α-SMA↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   VEGF↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL6↓, 1,   Inflam↓, 2,   JAK2↓, 1,   TNF-α↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

Half-Life↝, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   hepatoP↑, 1,   memory↑, 1,   toxicity↓, 1,  
Total Targets: 30

Scientific Paper Hit Count for: TOS, total oxidant status
5 Boron
1 Silver-NanoParticles
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:627  State#:%  Dir#:%
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