Database Query Results : , , COMT

COMT, catechol-O-methyl transferase: Click to Expand ⟱
Source:
Type:
Catechol-O-methyltransferase (COMT) is an enzyme located in the frontal cortex of the brain that metabolizes epinephrine, norepinephrine, and dopamine.
Genetic polymorphisms in the COMT gene can influence enzyme activity and may be associated with the risk of certain cancers.
COMT is involved in the metabolism of estrogens, particularly catechol estrogens, which can have both proliferative and genotoxic effects on breast tissue. Dysregulation of estrogen metabolism has been implicated in the development of hormone-related cancers.
Scientific Papers found: Click to Expand⟱
25- EGCG,  QC,    Quercetin Increased the Antiproliferative Activity of Green Tea Polyphenol (-)-Epigallocatechin Gallate in Prostate Cancer Cells
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP
COMT↓,
980- QC,    Dietary Quercetin Exacerbates the Development of Estrogen-Induced Breast Tumors in Female ACI Rats
- in-vivo, BC, NA
COMT↓, ROS∅,
81- QC,  EGCG,    Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea
- in-vivo, Pca, NA
COMT↓, MRP1↓, Ki-67↓, Bax:Bcl2↑, AR↓, Akt↓, p‑ERK↓, COMT↓, eff↑,
3193- SFN,    Epigenetic Therapeutics Targeting NRF2/KEAP1 Signaling in Cancer Oxidative Stress
- Review, Var, NA
DNMTs↓, HDAC↑, NRF2↑, DNMT1↓, DNMT3A↓, NQO1↑, COMT↑, TumCG↓, *toxicity↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

NQO1↑, 1,   NRF2↑, 1,   ROS∅, 1,  

Cell Death ⓘ

Akt↓, 1,   Bax:Bcl2↑, 1,  

DNA Damage & Repair ⓘ

DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,   HDAC↑, 1,   TumCG↓, 1,  

Migration ⓘ

Ki-67↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   COMT↓, 4,   COMT↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   MRP1↓, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   Ki-67↓, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: COMT, catechol-O-methyl transferase
3 Quercetin
2 EGCG (Epigallocatechin Gallate)
1 Sulforaphane (mainly Broccoli)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:64  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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