Database Query Results : , , PIAS-3

PIAS-3, Protein Inhibitor of Activated STAT-3: Click to Expand ⟱
Source:
Type:
PIAS-3 (Protein Inhibitor of Activated STAT-3) is a protein that plays a crucial role in regulating various cellular processes, including cell growth, differentiation, and survival. In the context of cancer, PIAS-3 has been found to have both tumor-suppressing and tumor-promoting effects, depending on the type of cancer and the specific cellular context.

In several cancers (e.g., glioblastoma, breast cancer, and lung cancers), reduced levels of PIAS3 have been reported.

– Downregulation of PIAS3 can result in unchecked STAT3 activity, which contributes to tumor progression and therapeutic resistance.
Scientific Papers found: Click to Expand⟱
424- CUR,    Curcumin inhibits autocrine growth hormone-mediated invasion and metastasis by targeting NF-κB signaling and polyamine metabolism in breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Src↓, p‑STAT1↓, p‑Akt↓, p‑p44↓, p‑p42↓, RAS↓, Raf↓, Vim↓, β-catenin/ZEB1↓, P53↓, Bcl-2↓, Mcl-1↓, PIAS-3↑, SOCS-3↑, SOCS1↑, ROS↑, NF-kB↓, PAO↑, SSAT↑, P21↑, Bak↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

PAO↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

p‑p42↓, 1,   Raf↓, 1,  

Core Metabolism/Glycolysis ⓘ

SSAT↑, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Bak↑, 1,   Bcl-2↓, 1,   Mcl-1↓, 1,  

DNA Damage & Repair ⓘ

P53↓, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

PIAS-3↑, 1,   RAS↓, 1,   Src↓, 1,   p‑STAT1↓, 1,  

Migration ⓘ

p‑p44↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,   SOCS-3↑, 1,   SOCS1↑, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PIAS-3, Protein Inhibitor of Activated STAT-3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:662  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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