Database Query Results : , , EM

EM, epithelial markers: Click to Expand ⟱
Source:
Type: marker
Epithelial markers are molecules commonly expressed by cells of epithelial origin. These markers include proteins such as E-cadherin, cytokeratins, epithelial cell adhesion molecule (EpCAM), and others. In the context of cancer, the expression of epithelial markers not only defines the cellular lineage but also provides insights into tumor differentiation, invasiveness, and the dynamic process of epithelial-to-mesenchymal transition (EMT). EMT is a critical event during which epithelial cells lose their polarity and cell–cell adhesion properties and gain migratory and invasive traits typically associated with mesenchymal cells.

Retained expression of epithelial markers generally correlates with lower invasiveness and a better patient prognosis, while a loss is often indicative of tumor aggressiveness and a greater potential for metastasis.
Scientific Papers found: Click to Expand⟱
1155- F,    The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations
- Review, NA, NA
*toxicity↓, Casp3↑, Casp7↑, Casp8↑, Casp9↑, VEGF↓, angioG↓, PI3K↓, Akt↓, PARP↑, Bak↑, BID↑, Fas↑, Mcl-1↓, survivin↓, XIAP↓, ERK↓, EMT↓, EM↑, IM↓, Snail↓, Slug↓, Twist↓,
1119- HNK,    Honokiol inhibits epithelial—mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E‐cadherin axis
- vitro+vivo, BC, NA
EMT↓, MSCmark↓, EM↑, STAT3↓, Zeb1↓, E-cadherin↑,
1125- LT,    Luteolin suppresses epithelial-mesenchymal transition and migration of triple-negative breast cancer cells by inhibiting YAP/TAZ activity
- in-vitro, BC, NA
YAP/TEAD↓, TAZ↓, MSCmark↓, EM↑, TumCMig↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

XIAP↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Bak↑, 1,   BID↑, 1,   Casp3↑, 1,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Fas↑, 1,   Mcl-1↓, 1,   survivin↓, 1,   YAP/TEAD↓, 1,  

DNA Damage & Repair ⓘ

PARP↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 2,   ERK↓, 1,   MSCmark↓, 2,   PI3K↓, 1,   STAT3↓, 1,   TAZ↓, 1,  

Migration EMT-like transitions, matrix degradation, and " style="cursor:help;color:#555;font-weight:normal;">ⓘ

E-cadherin↑, 1,   EM↑, 3,   Slug↓, 1,   Snail↓, 1,   TumCMig↓, 1,   Twist↓, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   VEGF↓, 1,  

Cellular Microenvironment ⓘ

IM↓, 1,  
Total Targets: 29

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: EM, epithelial markers
1 Fucoidan
1 Honokiol
1 Luteolin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:671  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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